Table 2:
ICE Chemical Quick Lists
| Chemical Quick Lists | Description1 | Reference Chemical List |
|---|---|---|
| AR In Vitro Agonist | 37 chemicals with androgen receptor agonist activity characterized in in vitro assays (Kleinstreuer et al., 2016a) | Yes |
| AR In Vitro Antagonist | 28 chemicals with androgen receptor antagonist activity characterized in in vitro assays (Kleinstreuer et al., 2016a) | Yes |
| AR In Vivo Agonists | 26 chemicals with androgen receptor agonist activity characterized in in vivo assays (Browne et al., 2018) | No |
| AR In Vivo Antagonists | 23 chemicals with androgen receptor antagonist activity characterized in in vivo assays (Browne et al., 2018) | No |
| EPA IRIS Carcinogenicity Classifications | 225 chemicals classified for weight of evidence of carcinogenicity according to the EPA Guidelines for Carcinogen Risk Assessment (https://www.epa.gov/risk/guidelines-carcinogen-risk-assessment) | No |
| ER In Vitro Agonist | 40 chemicals with estrogen receptor agonist activity characterized in vitro assays (Browne et al., 2015). 118 chemicals with estrogenic activity characterized in guideline-like rodent uterotrophic assays (Kleinstreuer et al., 2016b) | Yes |
| ER In Vivo Agonist | 43 chemicals with estrogenic activity characterized in guideline-like rodent uterotrophic assays (Kleinstreuer et al., 2016b) | Yes |
| Eye IrritationCorrosion | 123 chemicals recommended by ICCVAM for evaluating in vitro assays for eye irritation (https://ntp.niehs.nih.gov/go/40177) | Yes |
| IARC Classifications | 864 chemicals classified in IARC monographs evaluating carcinogenicity to humans. (https://monographs.iarc.fr/monographs-available/) | No |
| NTP Cancer Bioassay Chemicals |
542 chemicals from the NTP Technical Reports characterizing the toxicologic potential of agents in test animals. (https://ntp.niehs.nih.gov/publications/reports/index.html) |
No |
| RoC Classifications |
229 chemicals classified according to RoC listing criteria for human carcinogens. (https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/index.html) | No |
| Skin Corrosion | 32 chemicals recommended for assessing proficiency of conducting in vitro assays for skin corrosion (https://ntp.niehs.nih.gov/go/40193) | Yes |
| Steroidogenesis - Androgen | 36 chemicals with androgen synthesis effects characterized in the H295R steroidogenesis assay. (Pinto et al., 2018) | No |
| Steroidogenesis - Estrogen | 35 chemicals with estrogen synthesis effects characterized in the H295R steroidogenesis assay. (Pinto et al., 2018) | No |
| Thyroid | 34 chemicals with effects on thyroid activity characterized in up to three in vivo assays. (Wegner et al., 2016) | No |
| Tox21 | 9000+ chemicals tested in Tox21 Program. (https://tripod.nih.gov/tox21/assays/) | No |
1
Numbers and references are current as of February 2020