Table 2.
The associations between gene methylation and risk of breast cancer and different molecular types of breast cancer
| Molecular types a |
No. of Unmethylation(%) | No. of Methylation(%) | Crude OR (95% CI) |
P Value |
ORadjustedb (95% CI) |
P Value |
ORadjustedc (95% CI) |
P Value |
||
|---|---|---|---|---|---|---|---|---|---|---|
| WT1 | Control | 65(11.7) | 492(88.3) | 1 | 1 | 1 | ||||
| Luminal A | 9(6.4) | 132(93.6) | 1.99(0.94-4.23) | 0.07 | 2.61(1.18-5.74) | 0.02 | 2.62(1.11-6.20) | 0.03 | ||
| Luminal B | 8(6.0) | 125 (94.0) | 2.12(1.50-2.99) | 0.07 | 2.49(1.13-5.51) | 0.02 | 3.23(1.34-7.80) | 0.01 | ||
| HER-2 Enriched | 5(8.9) | 51(91.1) | 1.34(0.51-3.50) | 0.55 | 1.91(0.69-5.30) | 0.21 | 1.91(0.66-5.51) | 0.23 | ||
| TNBC | 1(2.9) | 33(27.1) | 4.34(0.58-32.33) | 0.15 | 5.63(0.73-43.63) | 0.10 | 6.04(0.76-47.90) | 0.09 | ||
| All cases | 26(6.5) | 376(93.5) | 1.92(1.18-3.13) | 0.01 | 2.42(1.45-4.04) | 0.01 | 3.07(1.67-5.64) | <0.01 | ||
| CA10 | Control | 209(37.5) | 348(62.5) | 1 | 1 | 1 | ||||
| Luminal A | 40(28.4) | 101(71.6) | 1.52(1.00-2.26) | 0.05 | 1.60(1.04-2.45) | 0.03 | 1.51(0.94-2.41) | 0.09 | ||
| Luminal B | 34(25.6) | 99(74.4) | 1.79(1.17-2.74) | 0.01 | 2.04(1.30-3.21) | <0.01 | 1.80(1.09-2.98) | 0.02 | ||
| HER-2 Enriched | 18(32.1) | 38(67.9) | 1.27(0.71-2.29) | 0.43 | 1.42(0.76-2.66) | 0.27 | 1.37(0.71-2.63) | 0.35 | ||
| TNBC | 14(41.1) | 20(58.8) | 0.86(0.43-1.74) | 0.67 | 0.94(0.45-1.96) | 0.87 | 1.01(0.46-2.20) | 0.99 | ||
| All cases | 119(29.6) | 283(70.4) | 1.43(1.08-1.88) | 0.01 | 1.53(1.14-2.05) | <0.01 | 1.35(0.97-1.90) | 0.08 |
aThe result excluded 38 breast cancer patients with incomplete immunohistochemical records
bAdjusted for age, BMI, ethnicity, urban and rural status and family history of breast cancer and cancer
cAdjusted by propensity score(potential confounder included age, BMI, urban and rural status, ethnicity, education level, mammography, gynecologic surgery, breast disease history, menstrual cycle, menopause, reproduction, abortion, breast feeding, oral contraceptive, female hormone intake, fruit intake, vegetable intake, tomato intake, broccoli intake, bean products, pungent food, pork, beef and lamb consumption, chicken consumption, sea-fish, egg, diary, fungus, pickles, alcohol consumption, tea consumption, cigarette, physical activity, occupation type, family history of breast cancer and cancer)