Table 4.
The associations between SNPs and euphoria associated with the first heroin use
| Gene | Variable/ID | Weak(n = 628) | Strong (n = 173) | Pa | OR, 95% CI | Pb | Exp(B), 95% CI | ||
|---|---|---|---|---|---|---|---|---|---|
| Number | Percent | Number | Percent | ||||||
| TH | rs10770140 | 0.047n | 0.791 | ||||||
| TT | 538 | 85.7 | 150 | 86.7 | 0.729 | 1.091, 0.667–1.785 | 0.741 | 1.088, 0.659–1.798 | |
| TC | 90 | 7.2 | 21 | 12.1 | 0.460 | 1.211,0.728–2.012 | 0.460 | 1.215, 0.724–2.037 | |
| CC | 0 | 0.0 | 2 | 1.2 | 0.046n | 1.012, 0.996–1.028 | 0.999 | 7,208,139,313, 0.000- | |
| T | 1166 | 92.8 | 321 | 92.8 | 0.970 | 1.009, 0.637–1.598 | |||
| C | 90 | 7.2 | 25 | 7.2 | |||||
| rs10770141 | 0.035n | 0.593 | |||||||
| GG | 544 | 86.6 | 153 | 88.4 | 0.529 | 1.181, 0.703–1.986 | 0.515 | 1.192, 0.702–2.025 | |
| GA | 84 | 6.7 | 18 | 10.4 | 0.299 | 1.329,0.775–2.278 | 0.283 | 1.351,0.780–2.342 | |
| AA | 0 | 0.0 | 2 | 1.2 | 0.046n | 1.012, 0.996–1.028 | 0.999 | 7,208,139,313, 0.000- | |
| G | 1172 | 93.3 | 324 | 93.6 | 0.827 | 0.947, 0.583–1.539 | |||
| A | 84 | 6.7 | 22 | 6.4 | |||||
Pa: Genotypic and allele frequency difference assessment by chi-square test
Pb: Genotypic and allele frequency difference assessment by binary logistic regression
n: The result was not significant after Bonferroni’s correction