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. 2020 Jun 24;63(4):395–406. doi: 10.5468/ogs.19210

Table 3.

Summary relative risk (RR) Estimates (95% confidence intervals [CIs]) for randomized controlled trial studies conducted on the effect of antenatal magnesium sulfate (MgSO4) on intraventricular hemorrhage in premature infants by gestational age, and MgSO4 regimen

Subgroup Number of studies (Sample size) Summery RR (95% CI) Between studies
Between subgroups
I2 P heterogeneity Q Q P heterogeneity
MgSO4 regimen
6 g loading and 2 g/h infusion 3 (6,592)a) 0.84 (0.72–0.98) 42.5% 0.345 7.07 6.07 0.048
4 g loading and 2 g/h infusion 3 (1,298)b) 1.13 (0.94–1.36) 27.8% 0.250 2.77
4 g single dose 2 (832)c) 0.86 (0.66–1.12) 0.0% 0.473 0.51
Gestational age (wk)
24 to 37 4 (7,654) 0.93 (0.83–1.05) 74.1% 0.009 11.57 16.21 0.013
<34 3 (1,842) 0.91 (0.70–1.18) 56.7% 0.099 4.62
a)

Hirtz et al. [24], Horton et al. [25], and Rouse et al. [29];

b)

Mirzamoradi et al. [27], Crowther et al. [10], and Mittendorf et al. [30];

c)

Marret et al. [26] and Mittendorf et al. [30].