Table 3.
Secular trends in maternal pre-pregnancy factors between 2006 and 2015
| Characteristics | 2006 (n=57,690) | 2007 (n=73,822) | 2008 (n=72,884) | 2009 (n=78,468) | 2010 (n=90,100) | 2011 (n=92,802) | 2012 (n=99,639) | 2013 (n=89,093) | 2014 (n=90,094) | 2015 (n=93,315) | P-value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Obesity | 7.13 | 7.03 | 7.34 | 7.74 | 8.42 | 8.76 | 9.09 | 9.29 | 9.87 | 10.67 | <0.01 |
| High AST | 0.80 | 0.68 | 0.66 | 0.74 | 0.87 | 0.88 | 0.93 | 0.97 | 1.03 | 1.07 | <0.01 |
| High ALT | 1.30 | 0.97 | 1.00 | 1.22 | 1.37 | 1.45 | 1.47 | 1.52 | 1.69 | 1.71 | <0.01 |
| High fasting glucose | 0.13 | 0.12 | 0.12 | 0.14 | 0.17 | 0.17 | 0.18 | 0.20 | 0.25 | 0.23 | <0.01 |
| High TC | 2.33 | 2.26 | 2.36 | 2.50 | 2.86 | 3.10 | 3.15 | 3.23 | 3.62 | 3.84 | <0.01 |
| Current smoking | 3.77 | 4.20 | 4.47 | 4.31 | 4.88 | 5.38 | 5.80 | 5.77 | 5.93 | 5.44 | <0.01 |
Values are presented as percentage. Obesity was defined as BMI ≥25 kg/m2. High LFTs were defined as AST and ALT levels of >31 U/L. High fasting glucose levels were defined as a glucose level of ≥126 mg/L. High cholesterol was defined as a cholesterol level of ≥200 mg/L.
AST, aspartate aminotransferase; ALT, alanine aminotransferase; TC, total cholesterol; BMI, body mass index; LFT, liver function test.