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. 2020 Jul 24;11:1501. doi: 10.3389/fimmu.2020.01501

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Copyright © 2020 Fernandes, Reilly, Schrock, Hocking, Oakes and Fowell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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pUR4-treated FN halts Th1 migration in vitro. (A) Schematic of in vitro Th1 migration under confinement. (B) Pre-treatment of Th1 cells with pUR4 or III-11C before loading under agar on FN coated coverslip, average speed per cell. (C,D) Pre-treatment of FN with pUR4 or III-11C before coating coverslip. (C) Average speed of Th1 cells under-agar on the different FN treated surfaces. (D) Displacement of Th1 cells on the different FN treated surfaces. Statistics by Mann Whitney, ****p < 0.0001. (E) Sample time-lapse sequences for Th1 cells (yellow) on III-11C pre-treated FN (left, center) and pUR4 pre-treated FN (right), color-coded time scale in mins. Two to four independent experiments, 300–400 cells per group per experiment (see Videos 4, 5).