Table 3.

The top five mappings of AOP68 to genes, pathways, diseases, other AOPs, and chemical species. AOP68: Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Proteome. P-value = 0.01.

Target profiles (No. mapped)	Target profile definition	Similarity score indirect
Genes (2060)		0.830–0.264
M_Rhoxl3	Reproductive homeobox 13	0.830
M_Rfx2	Regulatory factor x, 2	0.824
M_Nanos2	Nanos c2hc-type zinc finger 2	0.820
M_Nup210l	Nucleoporin 210-like	0.819
M_Hmgb2	High mobility group box 2	0.818
Pathways (435)		0.764–0.264
R-HSA-5601884	Piwi-interacting RNA biogenesis	0.764
R-MMU-1300652	Sperm oocyte membrane binding	0.737
R-MMU-1300642	Sperm motility and taxes	0.736
R-MMU-2046105	Linoleic acid metabolism	0.732
R-MMU-375281	Hormone ligand-binding receptors	0.722
Diseases (535)		0.815–0.283
M_OMIM_300200	Adrenal hypoplasia, congenital	0.815
M_OMIM_102530	Spermatogenic failure 6	0.803
M_OMIM_154230	46, XY sex reversal 4	0.790
M_OMIM_607080	46, XY gonadal dysgenesis, partial, with minifascicular neuropathy	0.790
M_OMIM_300068	Androgen insensitivity syndrome	0.777
AOPs (142)		0.849–0.157
AOP66	Modulation of adult leydig cell function subsequent glucocorticoid activation in the fetal testis	0.849
AOP67	Modulation of adult leydig cell function subsequent to estradiaol activation in the fetal testis	0.849
AOP74	Modulation of adult leydig cell function subsequent to hypermethylation in the fetal testis	0.822
AOP70	Modulation of adult leydig cell function subsequent to proteomic alterations in the adult leydig cell	0.723
AOP238	Excessive reactive oxygen species production leading to reduced ATP production-associated reproduction decline	0.712
CSPPs (15)		0.520–0.288
Atrazine_rat	Atrazine_rat	0.520
EE2_ZF	Ethinylestradiol_zebrafish	0.516
Malathion_rat	Malathion_rat	0.497
EE2_FHM	Ethinylestradiol_fathead minnow	0.485
Cypermethrin_rat	Cypermethrin_rat	0.483