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. 2020 Jul 24;10:379. doi: 10.3389/fcimb.2020.00379

Figure 3.

Figure 3

Glycoside hydrolases disperse P. aeruginosa and S. aureus biofilms from infected wound tissue. (A) P. aeruginosa PAO1 mono- and dual-species biofilms, and (B) S. aureus SA31 mono- and dual-species biofilms. (C) Image of infected tissue collected from murine wound bed. Infected wound tissue was treated with PBS (vehicle control), 5% amylase, 5% cellulase, or 10% GH containing both enzymes for 2 h. Percent dispersed was calculated as follows: (CFU in supernatant/ CFU in supernatant+ CFU in biofilm). Two-way ANOVA was used to determine significance comparing enzyme to PBS ###P < 0.001; ####P < 0.0001, or mono- to dual-species biofilm *P < 0.05; n = 5.