FIGURE 1.
Sugar or chow intake during microdialysis sessions on day 1 and 21. For the sugar drinking groups (top panel), there was no significant difference in sugar intake on day 1. By day 21, only the Daily Intermittent Sugar group showed a difference in intake relative to day 1. Rats in the Daily Intermittent Chow group ate the same amount on day 21 as on day 1 (bottom panel). Top panel: Daily Intermittent Sucrose (black bars); Sucrose Twice (gray bars); Daily Ad Libitum Sucrose (open bars). Bottom panel: Daily Intermittent Chow. *p<0.05. Reprinted with permission from Rada P, Avena NM, Hoebel BG. Daily bingeing on sugar repeatedly releases dopamine in the accumbens shell. Neuroscience. 2005;134(3):737–744.