Table 1.
Patient and treatment characteristics
| Total | ATM mut(−) | ATM mut(+) | p-value | |
|---|---|---|---|---|
| N = 39 | N = 29 | N = 10 | ||
| Median age [IQR], years | 59.0 [47.5;63.0] | 60.0 [52.0;64.0] | 49.0 [37.0;59.0] | 0.071 |
| < 60 years, n (%) | 22 (56.4) | 14 (48.3) | 8 (80.0) | 0.169 |
| ≥ 60 years, n (%) | 17 (43.6) | 15 (51.7) | 2 (20.0) | |
| Sex, n (%) | 0.727 | |||
| Male | 20 (51.3) | 14 (48.3) | 6 (60.0) | |
| Female | 19 (48.7) | 15 (51.7) | 4 (40.0) | |
| Preoperative KPS, n (%) | 0.580 | |||
| ≤ 80 | 28 (71.8) | 22 (75.9) | 6 (60.0) | |
| 90–100 | 11 (28.2) | 7 (24.1) | 4 (40.0) | |
| Subventricular zone, n (%) | 1.000 | |||
| Free | 5 (12.8) | 4 (13.8) | 1 (10.0) | |
| Involvement | 34 (87.2) | 25 (86.2) | 9 (90.0) | |
| Gliomatosis, n (%) | 0.515 | |||
| No | 21 (53.8) | 17 (58.6) | 4 (40.0) | |
| Yes | 18 (46.2) | 12 (41.4) | 6 (60.0) | |
| Pathology*, n (%) | 0.380 | |||
| Diffuse astrocytoma | 2 (5.1) | 2 (6.9) | 0 (0.0) | |
| Anaplastic astrocytoma | 10 (25.7) | 6 (20.7) | 4 (40.0) | |
| Glioblastoma | 27 (69.2) | 21 (72.4) | 6 (60.0) | |
| MGMT promoter, n (%) | 1.000 | |||
| Unmethylated | 15 (38.5) | 11 (37.9) | 4 (40.0) | |
| Methylated | 24 (61.5) | 18 (62.1) | 6 (60.0) | |
| Median Ki67 index [IQR], % | 15.0 [6.5;26.2] | 15.0 [6.5;27.5] | 17.5 [7.5;30.0] | 0.617 |
| < 15%, n (%) | 16 (41.0) | 12 (41.4) | 4 (40.0) | 1.000 |
| ≥ 15%, n (%) | 23 (59.0) | 17 (58.6) | 6 (60.0) | |
| Extent of resection, n (%) | 0.562 | |||
| Biopsy | 2 (5.1) | 2 (6.9) | 0 (0.0) | |
| Partial removal | 18 (46.2) | 14 (48.3) | 4 (40.0) | |
| Subtotal removal | 19 (48.7) | 13 (44.8) | 6 (60.0) | |
| Median total RT dose [IQR], Gy | 60.0 [60.0;60.0] | 60.0 [60.0;60.0] | 60.0 [60.0;60.0] | 0.600 |
| Median total RT fractions [IQR], fx | 30.0 [30.0;30.0] | 30.0 [30.0;30.0] | 30.0 [30.0;30.0] | 0.631 |
Abbreviations: IQR interquartile range, ATM ataxia-telangiectasia mutated gene, mut mutation, KPS Karnofsky performance status, MGMT O[6]-methylguanine-DNA methyltransferase, RT radiation therapy, Gy gray, fx fractions
* Pathology refers to the WHO grade