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. 2020 Jul 24;7:431. doi: 10.3389/fvets.2020.00431

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Copyright © 2020 Dickinson and Bannasch.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathological images of nucleus pulposus from 10 week-old control (CFA12 FGF4 retrogene –/–) (A, B) and 10 week-old homozygous CFA12 FGF4 retrogene (CFA12 FGF4 retrogene +/+) Nova Scotia (C, D) Duck Tolling Retriever puppies. The control nucleus pulposus has numerous normal physaliferous notochordal cells with foamy to vacuolated cytoplasm and often stellate cytoplasmic processes. By 10 weeks the CFA12 FGF4 retrogene-carrying dog's nucleus pulposus (B) consists predominantly of round to ovoid chondrocyte-like cells arranged either individually or in nodular clusters (arrow) associated with a dark purple chondroid matrix. Normal notochordal cells are rare. Both dogs have zero copies of the CFA18 FGF4 retrogene. H&E stain. Magnification (A, C) = 20X; (B, D) = 100X.