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. 2020 Jul 24;11:1608. doi: 10.3389/fimmu.2020.01608

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Copyright © 2020 Mohseni, Tung, Dudreuilh, Lechler, Fruhwirth and Lombardi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Alternatives to CAR monospecificity. (A) Pooled antigen specific CARs against two different antigens. CAR1 targeting Antigen 1 (Ag1), displaying an anti-Ag1 scFV, a CD28 extracellular region, a CD28 transmembrane domain, a CD28 signaling domain and a CD3ζ signaling domain, CAR2 targeting antigen 2 (Ag 2), with anti-Ag2 scFv. (B) Dual CAR—two different CARS connecting molecule to interact with the cell of interest. (C) Bi-specific or Tandem CAR—CAR able to interact with two different antigens. (D) Uni-CAR—using a connecting molecule to interact with the cell of interest. The CAR is displaying an anti-connecting molecule ScFv and the targeted cell has a receptor for the connecting molecule. Only approach tested with Tregs.