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. Author manuscript; available in PMC: 2020 Jul 31.
Published in final edited form as: Biochim Biophys Acta. 2016 Mar 9;1863(7 Pt B):1767–1771. doi: 10.1016/j.bbamcr.2016.03.005

Fig. 1.

Fig. 1.

Chromatin structure and major regulatory mechanisms. DNA is packaged by nucleosome units, each composed of ~147 bp of DNA (blue line) that wrap around histones (yellow). Such chromatin structure is controlled by three major regulatory mechanisms. Chromatin remodelers control the composition and position of nucleosomes. Histone modifiers catalyze covalent modifications of histones, which are recognized by histone readers. DNA modifiers, primarily DNA methyltransferases, are responsible for DNA methylation.