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. 2020 Jul 24;11:1099. doi: 10.3389/fphar.2020.01099

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Copyright © 2020 He, Yang, Hong, Huang, Zhu, Ye, Li, Zhang, Wei and Gao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vivo experiments to verify the inhibitory effect of dioscin on prostate cancer. (A, B) Dioscin inhibits tumor growth in BALB/c nude mice after tumor implantation with LNCaP-C81 or LNCaP cells (both p < 0.01). (C, D) Ki67 was used to assess tumor cell proliferation but did not change significantly between the groups (p > 0.05). (E, F) Dioscin promoted the expression of p-SHP1 (Y536) (p < 0.05) and inhibited p-Erk1/2 (T202/T204), p-P38 (T182), p-P38 (T180) and caspase-3 (35 KD) protein expression (all p < 0.01). It also significantly promoted the expression of caspase-3 (17/19KD) and Bad (all p < 0.01). Representative data from one of three independent experiments are shown in Figure 5 (C, E). * on behalf of p < 0.05; ** on behalf of p < 0.01.