Table 2.

In silico ADME parameters calculated for quinoline derivatives (compounds 1–5)

	1	2	3	4	5
MW	220.09	143.0	171.10	247.14	219.10
LogP	3.08	2.45	3.09	4.29	3.84
LogS	− 3.25	−2.51	− 3.34	− 4.81	− 4.20
%ABS	> 100	> 100	> 100	> 100	> 100
LogKp	− 5.31	− 5.33	− 4.94	− 4.39	− 4.64

MW, molecular weight < 500 g mol⁻¹; LogP, partition coefficient (< 5.0); LogS, solubility coefficient (> − 4); %ABS, percentage of oral absorption (> 100); LogKp, logarithm of cutaneous permeability; ADME, absorption, distribution, metabolism, excretion. The pharmacokinetic parameters were calculated through online platform SwissADME