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Is P2X7 good or bad in ALS? The “Death and Life” painting by Gustav Klimt (1910/15) well exemplifies the duality of purinergic P2X7 receptor in ALS. The main mechanisms and pathways involving P2X7 in ALS motor neurons (in blue color), oligodendrocytes (in yellow), microglia (in green), and muscle (in pink) pathology are listed in the figure. In brown are written the pathways shared between neurons and microglia.
