Table 2.
Assisted reproductive technology outcomes in poor responders undergoing follicular flushing and direct aspiration
| Primary outcomes | Follicular flushing Group A (n=35) | Direct aspiration Group B (n=36) | p | Difference between means or proportion | 95% confidence limits | |
|---|---|---|---|---|---|---|
| Lower limit | Upper limit | |||||
| Total number of oocytes retrievedc | 4.5 ± 1.7 | 3.7 ± 1.9 | 0.066 | 0.79 | −0.05 | 1.6 |
| Total number of MII oocytesc | 2 (2-3) | 2.5 (1-3) | 0.907 | - | - | - |
| Secondary outcomes | ||||||
| Fertilization ratea | 0.73 ± 0.29 | 0.68 ± 0.34 | 0.537 | 0.05 | −0.10 | 0.19 |
| Cleavage ratec | 1 (0-1) | 1 (0-1) | 0.716 | - | - | - |
| Total number of embryosc | 4 (2-4) | 3 (2-4) | 0.073 | - | - | - |
| Number of Grade 1 embryosc | 3 (2-3) | 2 (1-3) | 0.075 | - | - | - |
| Number of embryos transferreda | 2.6±1.1 | 2.2 ± 1.2 | 0.148 | 0.41 | −0.15 | 0.96 |
| Failed oocyte recovery, n (%)b | 2/35 (5.7) | 4/36 (11.4) | 0.421 | −0.054 | −0.187 | 0.079 |
| Failed fertilization, n (%)b | 1/35 (2.8) | 0/36 (0) | 0.328 | −0.028 | −0.084 | 0.028 |
| Implantation rate, n (%)b | 8/74 (10.8) | 2/72 (2.8) | 0.098 | 8 | 0 | 17.4 |
| Clinical pregnancy rate, n (%)b | 8/35 (22.9) | 2/36 (5.6) | 0.046 | 17.3 | 0.007 | 34.0 |
| Miscarriage rate, n (%)b | 4/35 (11.4) | 0/36 (0) | 0.054 | 11.4 | 0 | 26.0 |
| Live birth rate, n (%)b | 4/35 (11.4) | 2/36 (5.6) | 0.429 | 5.9 | 0 | 20.9 |
| Anesthesia timea | 36.7 ± 8.6 | 19.1 ± 3.7 | <0.001 | 17.6 | 14.5 | 20.7 |
| Procedure timea | 8.2 ± 3.4 | 3.8 ± 1.5 | <0.001 | 4.4 | 3.2 | 5.6 |
Data were presented as aMean±SD, bn (%), cMedian (minimum–maximum). SD=Standard deviation, MII=Metaphase II