Table 1.

Potential protein targets of TRYP and E/Z isomers of TRYP-Ox.

Compound	Rank	PDB ID	Fit score	Target name*
TRYP	1	1XLV	0.7668	AChE
	2	1YA8	0.7459	CES-1
	3	1E5A	0.7456	TTR
	36	2H96	0.5262	JNK1
	47	3FV8	0.4908	JNK3
	>146	–	–	CFB
(E)TRYP-Ox	1	1UKI	0.9836	JNK1
	2	1PMV	0.964	JNK3
	3	1RS0	0.9423	CFB
	4	1DVZ	0.9349	TTR
	6	1YA8	0.8217	CES-1
	18	1XLV	0.7108	AChE
(Z)TRYP-Ox	1	1UKI	0.9836	JNK1
	2	1PMV	0.964	JNK3
	3	1RS0	0.9423	CFB
	7	1YA8	0.7565	CES-1
	11	1E5A	0.7242	TTR
	>172	–	–	AChE

*AChE, acetylcholinesterase; CES-1, carboxylesterase 1; TTR, transthyretin; CFB, complement factor B; JNK, c-Jun N-terminal kinase. The top 3 targets for each compound are highlighted in bold.