Table 3.
Changes in the microRNA expression observed in psoriatic skin and peripheral blood cells
| miRNA | Target genes | Tissue/cell | Process | References |
|---|---|---|---|---|
| ↑ mR-31 | Ppp6c, FIH-1, STK40 | Skin/PBMC | G1/S phase regulator, regulation NF-κB activity, ↑ Kc differentiation and proliferation, T cell activation, angiogenesis, and leukocyte migration to the skin ↑ inflammation | 69, 102, 103, 105, 118, 119, 136 |
| ↑ miR-203 | SOCS-3, SOCS-6, p63, TNFα, IL8, IL24 | Skin | STAT3 signaling, ↑ Kc differentiation and proliferation, ↑ inflammation | 69, 110, 111, 125, 137, 138 |
| ↓ miR-99a | IGF-1R | Skin | ↑ Kc differentiation and ↓ proliferation | 104, 119, 125 |
| ↓ miR125b | FGFR-2, TNFα, P63, NOTCH1 | Skin | ↑ Kc differentiation and ↓ proliferation | 69, 103, 120, 128 |
| ↑ miR-21 | TIMP3, TM1, ODCD4, PTEN, IL12A, RECK, RTN4, NF1B | Skin, PBMC | ↑ Kc differentiation and proliferation, T cell activation, ↑ TNF-α, ↑ inflammation | 69, 103–105, 118, 119, 122, 138 |
| ↑ miR-135b | COL4A3 | Skin | Kc differentiation and proliferation | 1103, 119, 126 |
| ↑ miR146a | IRAK, TRAF6, EGFR | Skin/PBMC | Hematopoiesis, inflammation, keratinocyte proliferation | 69, 103–105, 119, 136 |
| ↑ miR-155 | ↓ CTLA-4 | Skin | Inflammation,↓ Treg function | 104, 114, 119 |
| ↑ miR-210 | ↓ FOXP3 | PBMCs | ↓ Treg activation, ↑ differentiation of Th1 and Th17, ↓ Th2 differentiation | 115 |
| ↑ miR-184 | AGO2 | Skin | Regulation of posttranscriptional modification of mRNA and miRNA biogenesis via the miRISC complex | 124 |
| ↑ miR221/222 | ↓ TIMP3, c-KIT, P53 | Skin | Kc and immune cells proliferation | 118, 136 |
| ↑ miR-424 | MEK1, cyclin E1 | Skin | Kc differentiation and proliferation | 104, 125 |