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. Author manuscript; available in PMC: 2021 Jun 25.
Published in final edited form as: Cell. 2020 Jun 16;181(7):1533–1546.e13. doi: 10.1016/j.cell.2020.05.036

Figure 2. Gut microbiome composition contributes to V. cholerae infection resistance.

Figure 2.

V. cholerae colonization in germfree adult mice harboring defined model communities co-gavaged with V. cholerae in (A) feces and (B) small intestines 4 days post infection. (C) Fecal V. cholerae colonization in GF adult mice harboring defined communities for 2 weeks and then gavaged with V. cholerae. Mix: 10 days DS colonization, followed by a SR microbes 4 days prior to V. cholerae infection. (D) Intestinal V. cholerae colonization of GF suckling mice co-gavaged with model communities and V. cholerae. (E) Intestinal V. cholerae colonization of antibiotic-treated CD-1 suckling mice co-gavaged with indicated communities. (F) 16S gene abundance in small intestine. (G) Expression of tcpA in infected mice with model human microbiomes. (H) T6SS effects on small intestine colonization in antibiotic-treated CD-1 pups. * P<0.05, ** P<0.01, *** P<0.001 (Mann-Whitney U-test); n.s. not significant. Error bars represent mean ± SEM. n=6–12 animals for all experiments.

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