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. Author manuscript; available in PMC: 2021 Jun 25.
Published in final edited form as: Cell. 2020 Jun 16;181(7):1533–1546.e13. doi: 10.1016/j.cell.2020.05.036

Figure 7. Levels of B. obeum bsh enzymes in human samples correlate to infection outcome, and can independently modulate V. cholerae colonization.

Figure 7.

(A) Levels of phylotype 1 bsh enzymes in metagenomic sequencing of fecal microbiomes of cholera patients pre- (“Diarrhea (d0)”) and post-antibiotic (“Diarrhea + abx”) treatment, compared to healthy adults in Bangladesh. (B) Mass spectrometry measurement of bile levels in 125μM solutions of TC incubated with indicated cultured human fecal communities in vitro, †: TC not detected. (C) B. obeum bsh levels in intestines of antibiotic-cleared suckling CD-1 mice colonized with complex human fecal samples without V. cholerae, compared to V. cholerae colonization of antibiotic-cleared suckling animals bearing human donor microbiomes. * P<0.05, ** P<0.01, *** P<0.001 (Mann-Whitney U-test). Error bars represent mean ± SEM.

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