Table 1.
Demographic Characteristics.
| Age of Onset Groups | ALL | |||||||
|---|---|---|---|---|---|---|---|---|
| Young onset (20–29 years) |
Typical onset (30–59 years) |
Late onset (60+ years) |
||||||
| N | % | N | % | N | % | N | % | |
| TFC stage | ||||||||
| Stage I (11–13) | 191 | 31.31 | 1864 | 32.30 | 278 | 30.18 | 2333 | 31.95 |
| Stage II (7–10) | 198 | 32.46 | 2025 | 35.09 | 347 | 37.68 | 2570 | 35.20 |
| Stage III (3–6) | 139 | 22.79 | 1265 | 21.92 | 215 | 23.34 | 1619 | 22.17 |
| Stage IV (1–2) | 54 | 8.85 | 445 | 7.71 | 67 | 7.27 | 566 | 7.75 |
| Stage V (0) | 28 | 4.59 | 172 | 2.98 | 14 | 1.52 | 214 | 2.93 |
| TFC stage | ||||||||
| Early (Stage I & II) | 389 | 63.77 | 3889 | 67.39 | 625 | 67.86 | 4903 | 67.15 |
| Moderate (Stage III) | 139 | 22.79 | 1265 | 21.92 | 215 | 23.34 | 1619 | 22.17 |
| Advanced (Stage IV & V) | 82 | 13.44 | 617 | 10.69 | 81 | 8.79 | 780 | 10.68 |
| Sex | ||||||||
| Female | 319 | 52.12 | 2998 | 51.90 | 445 | 48.21 | 3762 | 51.46 |
| Male | 293 | 47.88 | 2778 | 48.10 | 478 | 51.79 | 3549 | 48.54 |
| Race | ||||||||
| Other | 41 | 6.70 | 335 | 5.80 | 39 | 4.23 | 415 | 5.68 |
| White/Caucasian | 571 | 93.30 | 5441 | 94.20 | 884 | 95.77 | 6896 | 94.32 |
| Has Mother Affected | 279 | 46.66 | 2660 | 47.75 | 365 | 45.23 | 3304 | 47.36 |
| Has Father Affected | 308 | 51.85 | 2602 | 47.12 | 278 | 34.71 | 3188 | 46.09 |
| Has Family History | 526 | 85.95 | 4866 | 84.25 | 788 | 85.37 | 6180 | 84.53 |
| Marital Status | ||||||||
| Married/Partnership | 199 | 32.52 | 3782 | 65.56 | 691 | 74.95 | 4672 | 63.97 |
| Single/Divorced/Widowed/Legally Separated | 413 | 67.48 | 1987 | 34.44 | 231 | 25.05 | 2631 | 36.03 |
| ISCED Education Level | ||||||||
| Less than or equal to 12th grade | 374 | 61.41 | 3217 | 55.96 | 541 | 58.87 | 4132 | 56.78 |
| Higher than 12th grade | 235 | 38.59 | 2532 | 44.04 | 378 | 41.13 | 3145 | 43.22 |
| Employment Status | ||||||||
| Employed | 129 | 21.11 | 1302 | 22.59 | 79 | 8.60 | 1510 | 20.70 |
| Not Employed | 482 | 78.89 | 4461 | 77.41 | 840 | 91.40 | 5783 | 79.30 |
| Rater’s Judgement of Initial Major Symptom | ||||||||
| Motor | 269 | 44.39 | 2966 | 51.51 | 631 | 68.36 | 3866 | 53.05 |
| Cognitive | 46 | 7.59 | 489 | 8.49 | 42 | 4.55 | 577 | 7.92 |
| Psychiatric | 165 | 27.23 | 1197 | 20.79 | 104 | 11.27 | 1466 | 20.12 |
| Oculomotor/Other/Mixed | 126 | 20.79 | 1106 | 19.21 | 146 | 15.82 | 1378 | 18.91 |
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | |
| BMI | 24.32 | 5.43 | 25.03 | 5.03 | 25.02 | 4.31 | 24.97 | 4.99 |
| Age of clinical HD diagnosis | 29.83 | 6.25 | 48.27 | 8.72 | 67.92 | 5.57 | 49.22 | 11.99 |
| Larger research CAG allele determined from DNA | 49.81 | 4.67 | 43.59 | 2.49 | 40.75 | 1.19 | 43.75 | 3.34 |
Missing values were encountered in 9 (0.12%) for TFC score, 335 (4.58%) for mother affected, 394 (5.39%) for father affected, 8 (0.11%) for marital status, 34 (0.47%) for education level, 18 (0.25%) for employment status, 24 (0.33%) for rater’s judgement of initial major symptom, 235 (3.21%) in BMI, and 140 (1.91%) in age of clinical HD diagnosis.