Table 2.
Motor and Cognitive Variables by Age of Onset Groups and TFC Stages.
| TFC Score Category | Young | Typical | Late | P-value | ||||
|---|---|---|---|---|---|---|---|---|
| N | Median (Q1–Q3) or N (%) | N | Median (Q1–Q3) or N (%) | N | Median (Q1–Q3) or N (%) | |||
| Motor Symptoms | ||||||||
| UHDRS Motor score (TMS) | Early | 387 | 25.00 (15.00, 38.00) | 3871 | 27.00 (18.00, 38.00) | 619 | 30.00 (20.00, 39.00) | * <0.01 |
| Moderate | 139 | 56.00 (39.00, 67.00) | 1248 | 51.00 (38.50, 63.00) | 214 | 51.00 (39.00, 60.00) | 0.13 | |
| Advanced | 80 | 83.00 (70.00, 91.50) | 609 | 75.00 (63.00, 87.00) | 79 | 65.00 (53.00, 77.00) | * <0.01 | |
| Timed “Up and Go” Total time | Early | 190 | 8.75 (7.00, 11.00) | 1661 | 9.00 (7.40, 11.00) | 252 | 10.00 (8.80, 13.00) | * <0.01 |
| Moderate | 45 | 11.00 (9.00, 15.00) | 462 | 12.00 (9.50, 16.00) | 63 | 14.00 (11.00, 20.00) | * 0.02 | |
| Advanced | 10 | 14.00 (12.00, 21.00) | 72 | 15.50 (10.00, 23.00) | 12 | 17.00 (15.00, 26.50) | 0.47 | |
| Cognitive Symptoms | ||||||||
| Symbol Digit Modality Test Total correct % | Early | 384 | 100.00 (93.75, 100.00) | 3819 | 100.00 (95.00, 100.00) | 609 | 100.00 (93.33, 100.00) | * 0.02 |
| Moderate | 118 | 100.00 (86.67, 100.00) | 1104 | 96.23 (86.36, 100.00) | 187 | 95.00 (75.00, 100.00) | 0.13 | |
| Advanced | 52 | 0.00 (0.00, 87.78) | 398 | 0.00 (0.00, 94.74) | 45 | 50.00 (0.00, 100.00) | 0.16 | |
| Verbal Fluency Test Total correct % Category | Early | 384 | 100.00 (93.22, 100.00) | 3847 | 100.00 (90.91, 100.00) | 622 | 100.00 (90.91, 100.00) | * 0.01 |
| Moderate | 134 | 100.00 (87.50, 100.00) | 1227 | 100.00 (85.71, 100.00) | 210 | 100.00 (83.33, 100.00) | 0.41 | |
| Advanced | 65 | 85.71 (0.00, 100.00) | 491 | 85.71 (40.00, 100.00) | 67 | 100.00 (75.00, 100.00) | * 0.03 | |
| Verbal Fluency Test Total correct % Letter | Early | 300 | 95.45 (90.12, 100.00) | 3037 | 95.00 (88.89, 100.00) | 456 | 94.12 (87.50, 100.00) | 0.18 |
| Moderate | 92 | 94.28 (85.96, 100.00) | 854 | 92.98 (82.61, 100.00) | 155 | 90.00 (76.00, 100.00) | * <0.01 | |
| Advanced | 41 | 80.95 (0.00, 100.00) | 277 | 76.47 (50.00, 100.00) | 41 | 85.71 (61.54, 100.00) | 0.44 | |
| Stroop Color Naming Test Total correct % | Early | 381 | 100.00 (100.00, 100.00) | 3833 | 100.00 (100.00, 100.00) | 614 | 100.00 (100.00, 100.00) | 0.84 |
| Moderate | 133 | 100.00 (98.63, 100.00) | 1206 | 100.00 (98.08, 100.00) | 202 | 100.00 (97.50, 100.00) | 0.78 | |
| Advanced | 64 | 98.49 (0.00, 100.00) | 468 | 97.26 (0.00, 100.00) | 60 | 98.53 (64.38, 100.00) | 0.82 | |
| Stroop Word Reading test Total correct % | Early | 381 | 100.00 (100.00, 100.00) | 3831 | 100.00 (100.00, 100.00) | 614 | 100.00 (100.00, 100.00) | 0.18 |
| Moderate | 129 | 100.00 (100.00, 100.00) | 1187 | 100.00 (100.00, 100.00) | 200 | 100.00 (100.00, 100.00) | 0.65 | |
| Advanced | 63 | 96.67 (0.00, 100.00) | 457 | 100.00 (0.00, 100.00) | 60 | 100.00 (0.00, 100.00) | 0.19 | |
| Stroop Interference Test Total correct % | Early | 356 | 100.00 (96.08, 100.00) | 3511 | 100.00 (96.15, 100.00) | 548 | 100.00 (95.00, 100.00) | 0.24 |
| Moderate | 106 | 100.00 (88.89, 100.00) | 956 | 100.00 (87.50, 100.00) | 155 | 94.74 (76.92, 100.00) | * 0.02 | |
| Advanced | 38 | 95.00 (36.84, 100.00) | 281 | 88.24 (16.67, 100.00) | 33 | 84.62 (30.00, 100.00) | 0.53 | |
| Mini Mental State Examination (MMSE) score | Early | 270 | 26.00 (24.00, 29.00) | 2562 | 27.00 (25.00, 29.00) | 393 | 27.00 (25.00, 28.00) | 0.13 |
| Moderate | 80 | 24.00 (20.00, 26.50) | 725 | 23.00 (20.00, 26.00) | 128 | 23.00 (19.00, 25.00) | 0.08 | |
| Advanced | 34 | 17.00 (11.00, 22.00) | 252 | 17.00 (13.00, 21.00) | 37 | 18.00 (15.00, 22.00) | 0.68 | |
* Significant at level p < 0.05.