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. Author manuscript; available in PMC: 2021 Jul 24.
Published in final edited form as: J Mol Biol. 2020 Jun 17;432(16):4623–4636. doi: 10.1016/j.jmb.2020.06.013

Figure 2. Crystal structure of sRI-sT complex (PDB = 6PSK, 6PXE).

Figure 2.

A Ribbon diagram of hetero-tetramer observed in crystals of the sRI-sT complex. sRI subunits are colored in light blue, and sT - in tan.

B Surface representation of the sRI-sT complex colored by electrostatic potential, the orientation is the same as on the panel A.

C 90° rotated view of the sRI-sT complex depicted on the panel A. GAF domain homolog structure (pdb ID: 2ool) shown as green licorice ribbon is superimposed on both sT subunits for a comparison. Putative positions for the elements not covered by the crystal structure are shown as dash outlined boxes: blue for the SAR domains of RI, and red for the transmembrane (TM) helix and α0 of T.

D Elements of the structure are marked on the ribbon representation of the sRI bound form of the sT. Clipped surface view of the overlaid GAF domain homolog structure (pdb ID: 2ool) is shown in green to illustrate that LC loop of sT blocks putative GAF pocket (highlighted by purple line).