Table 10.

Physicochemical properties and in vitro binding and metabolism

Cmpd	37	1a
MW	323	415
Log D 7.4	2.8b	4.0c
Solubility (μg/mL)
FaSSGF (pH 1.6)	46.4	6.8
FaSSIF (pH 6.5)	60.1	5.1
FeSSIF (pH 5.8)	115	27.6
PBS (pH 7.4)	45.6	2.0
H/R/M plasma protein binding (% bound)	90.0 / 88.2 / 88.9	99.9 / 97.0 / 99.7
Albumax binding (% bound)	51.8	83.1
Microsome binding (% bound)	29.9	71.7
DMEM/10% FCS binding (% bound)	31.5	78.5
H/R/M CLint (μL/min/mg)	10 / 14 / 24	<7 / <7 / <7

^aData from²².

^bchromatographic

^cshake flask

Human (H), rat (R), mouse (M)