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. Author manuscript; available in PMC: 2021 May 14.
Published in final edited form as: J Med Chem. 2020 Apr 16;63(9):4929–4956. doi: 10.1021/acs.jmedchem.0c00311

Table 7:

Bridge modifications

Cmpd CmpdID Structure IC50 (μM) EC50 (μM)
PfDHODH PvDHODH hDHODH Pf3D7 cellsa
69 DSM504 graphic file with name nihms-1611507-t0100.jpg 21 (17–25) nd nd 6.5 (6.0–7.0)
71 DSM505 graphic file with name nihms-1611507-t0101.jpg >100 (2) nd nd >10, >20
73 DSM558 graphic file with name nihms-1611507-t0102.jpg 0.074 (0.059–0.092) 0.23 (0.18–0.29) >100 0.044 (0.038–0.052)
74 DSM537 graphic file with name nihms-1611507-t0103.jpg 0.8 (0.68–0.94) 0.16 (0.10–0.25) >100 0.29 (0.24–0.36)

See Table 1 footnote.