| The presence of MSU is pathognomonic for urate arthritis (gout), while calcium pyrophosphate dihydrate (CPPD) crystals are associated with chondrocalcinosis (pseudogout). Synovial fluid crystal analysis should be performed using (direct or compensated) polarizing light microscopy (PLM). Slides should be prepared using cytocentrifuged SF samples to increase the sensitivity of crystal detection (5, 8, 11, 12, 18). |
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