Table 2.
The correlation between TNFAIP2 TagSNPs and gastric cancer (GC) risk in the general population.
| TNFAIP2 SNPs | GC (%) | Control (%) | P-value* | OR* (95% CI) |
|---|---|---|---|---|
| rs8126 | n = 1125 | |||
| n = 587 | n = 538 | |||
| TT | 272 (46.4) | 205 (38.1) | 1 (Ref) | |
| TC | 235 (40.0) | 270 (50.2) | 0.001 | 1.557 (1.188–2.041) |
| CC | 80 (13.6) | 63 (11.7) | 0.901 | 1.026 (0.685–1.536) |
| CC + TC vs. TT | 0.007 | 1.419 (1.099–1.832) | ||
| CC vs. TC + TT | 0.298 | 0.818 (0.561–1.194) | ||
| PHWE | 0.067 | |||
| rs710100 | n = 1115 | |||
| n = 543 | n = 572 | |||
| CC | 217 (40.0) | 214 (37.4) | 1 (Ref) | |
| CT | 251 (46.2) | 285 (49.8) | 0.545 | 0.920 (0.701–1.206) |
| TT | 75 (13.8) | 73 (12.8) | 0.545 | 1.131 (0.156–0.332) |
| TT + CT vs. CC | 0.805 | 0.968 (0.747–1.254) | ||
| TT vs. CT + CC | 0.329 | 1.202 (0.831–1.738) | ||
| PHWE | 0.145 | |||
| rs3759571 | ||||
| n = 578 | n = 584 | |||
| GG | 239 (41.3) | 230 (39.4) | 1 (Ref) | |
| GA | 268 (46.4) | 278 (47.6) | 0.597 | 0.931 (0.715–1.213) |
| AA | 71 (12.3) | 76 (13.0) | 0.926 | 0.981 (0.662–1.455) |
| AA + GA vs. GG | 0.672 | 0.947 (0.736–1.218) | ||
| AA vs. GA + GG | 0.882 | 1.028 (0.711–1.488) | ||
| PHWE | 0.575 | |||
| rs3759573 | ||||
| n = 529 | n = 554 | |||
| AA | 179 (33.8) | 184 (33.2) | 1 (Ref) | |
| AG | 291 (55.0) | 302 (54.5) | 0.858 | 1.026 (0.774–1.361) |
| GG | 59 (11.2) | 68 (12.3) | 0.778 | 0.941 (0.614–1.440) |
| GG + AG vs. AA | 0.918 | 1.014 (0.773–1.331) | ||
| GG vs. AG + AA | 0.766 | 0.942 (0.633–1.400) | ||
| PHWE | 0.001# | |||
*
Adjusted for gender, age, and H. pylori infection.
#
The results were inconsistent with Hardy–Weinberg genetic linkage equilibrium. Bold Values indicate the data is statistically significant differences (P < 0.05).