Table 3.
The correlation between TNFAIP2 TagSNPs and gastric cancer (GC) risk in the subgroup population.
| Parameters | Genotype | GC vs. control | P-value* | OR (95%) |
|---|---|---|---|---|
| rs8126 | ||||
| Gender# | n = 587 vs. 538 | |||
| Male | TT | 195/149 | ||
| TC | 171/201 | 0.005 | 1.573 (1.143–2.164) | |
| CC | 55/45 | 0.841 | 1.051 (0.648–1.703) | |
| CC + TC vs. TT | 0.018 | 1.443 1.066–(1.954) | ||
| CC vs. TC + TT | 0.407 | 0.825 (0.524–1.300) | ||
| Female | TT | 77/56 | ||
| TC | 64/69 | 0.116 | 1.510 (0.903–2.525) | |
| CC | 25/18 | 0.866 | 1.067 (0.500–2.275) | |
| CC + TC vs. TT | 0.193 | 1.374 (0.852–2.216) | ||
| CC vs. TC + TT | 0.642 | 0.849 (0.425–1.694) | ||
| Age (years) | n = 587 vs. 538 | |||
| ≥60 | TT | 129/74 | ||
| TC | 126/124 | 0.005 | 1.816 (1.195–2.758) | |
| CC | 34/25 | 0.493 | 1.257 (0.653–2.420) | |
| CC + TC vs. TT | 0.010 | 1.693 (1.135–2.526) | ||
| CC vs. TC + TT | 0.718 | 0.895 (0.488–1.638) | ||
| <60 | TT | 143/131 | ||
| TC | 109/146 | 0.049 | 1.440 (1.002–2.069) | |
| CC | 46/38 | 0.788 | 0.931 (0.551–1.572) | |
| CC + TC vs. TT | 0.138 | 1.292 (0.921–1.811) | ||
| CC vs. TC + TT | 0.321 | 0.780 (0.477–1.274) | ||
| H. pylori infection# | n = 587 vs. 538 | |||
| Positive | TT | 137/35 | ||
| TC | 121/46 | 0.084 | 1.569 (0.941–2.618) | |
| CC | 41/9 | 0.757 | 0.879 (0.386–1.997) | |
| CC + TC vs. TT | 0.186 | 1.391 (0.853–2.266) | ||
| CC vs. TC + TT | 0.361 | 0.698 (0.322–1.511) | ||
| Negative | TT | 135/170 | ||
| TC | 114/224 | 0.006 | 1.560 (1.133–2.147) | |
| CC | 39/54 | 0.693 | 1.099 (0.687–1.759) | |
| CC + TC vs. TT | 0.017 | 1.440 (1.067–1.944) | ||
| CC vs. TC + TT | 0.563 | 0.878 (0.564–1.365) | ||
| Smoking | n = 246 vs. 314 | |||
| Yes | TT | 47/44 | ||
| TC | 34/62 | 0.182 | 1.556 (0.813–2.979) | |
| CC | 16/10 | 0.615 | 0.770 (0.277–2.135) | |
| CC + TC vs. TT | 0.377 | 1.318 (0.715–2.432) | ||
| CC vs. TC + TT | 0.232 | 0.560 (0.216–1.450) | ||
| No | TT | 76/74 | ||
| TC | 56/99 | 0.038 | 1.701 (1.030–2.809) | |
| CC | 17/25 | 0.298 | 1.501 (0.699–3.227) | |
| CC + TC vs. TT | 0.038 | 1.643 (1.027–2.627) | ||
| CC vs. TC + TT | 0.750 | 1.123 (0.549–2.298) | ||
| Drinking | n = 246 vs. 311 | |||
| Yes | TT | 39/30 | ||
| TC | 29/43 | 0.089 | 1.831 (0.913–3.674) | |
| CC | 12/6 | 0.579 | 0.718 (0.222–2.317) | |
| CC + TC vs. TT | 0.216 | 1.518 (0.784–2.940) | ||
| CC vs. TC + TT | 0.233 | 0.515 (0.174–1.531) | ||
| No | TT | 84/87 | ||
| TC | 61/117 | 0.045 | 1.630 (1.010–2.629) | |
| CC | 21/28 | 0.524 | 1.258 (0.620–2.552) | |
| CC + TC vs. TT | 0.065 | 1.524 (0.974–2.384) | ||
| CC vs. TC + TT | 0.873 | 0.947 (0.485–1.851) | ||
| rs710100 | n = 543 vs. 572 | |||
| Gender# | ||||
| Male | CC | 151/166 | ||
| CT | 182/209 | 0.913 | 0.982 (0.713–1.352) | |
| TT | 49/52 | 0.649 | 1.119 (0.689–1.816) | |
| TT + CT vs. CC | 0.950 | 1.010 (0.744–1.371) | ||
| TT vs. CT + CC | 0.567 | 1.140 (0.728–1.787) | ||
| Female | CC | 66/48 | ||
| CT | 69/76 | 0.251 | 0.738 (0.440–1.239) | |
| TT | 26/21 | 0.877 | 1.060 (0.505–2.228) | |
| TT + CT vs. CC | 0.427 | 0.818 (0.499–1.342) | ||
| TT vs. CT + CC | 0.439 | 1.298 (0.670–2.512) | ||
| Age (years) | n = 543 vs. 572 | |||
| ≥60 | CC | 106/78 | ||
| CT | 131/131 | 0.373 | 0.827 (0.544–1.257) | |
| TT | 33/24 | 0.461 | 1.290 (0.656–2.536) | |
| TT + CT vs. CC | 0.581 | 0.892 (0.594–1.339) | ||
| TT vs. CT + CC | 0.274 | 1.410 (0.761–2.612) | ||
| <60 | CC | 111/136 | ||
| CT | 120/154 | 0.860 | 0.968 (0.673–1.391) | |
| TT | 42/49 | 0.787 | 1.074 (0.641–1.800) | |
| TT + CT vs. CC | 0.999 | 1.000 (0.710–1.409) | ||
| TT vs. CT + CC | 0.608 | 1.131 (0.706–1.812) | ||
| H. pylori infection# | n = 543 vs. 572 | |||
| Positive | CC | 112/47 | ||
| CT | 124/44 | 0.536 | 1.168 (0.714–1.910) | |
| TT | 36/7 | 0.080 | 2.227 (0.908–5.462) | |
| TT + CT vs. CC | 0.258 | 1.313 (0.819–2.104) | ||
| TT vs. CT + CC | 0.104 | 2.031 (0.865–4.768) | ||
| Negative | CC | 105/167 | ||
| CT | 127/241 | 0.272 | 0.833 (0.601–1.155) | |
| TT | 39/66 | 0.676 | 0.905 (0.566–1.446) | |
| TT + CT vs. CC | 0.313 | 0.853 (0.625–1.162) | ||
| TT vs. CT + CC | 0.945 | 1.015 (0.661–1.560) | ||
| Smoking | n = 228 vs. 337 | |||
| Yes | CC | 37/48 | ||
| CT | 40/66 | 0.451 | 0.785 (0.418–1.474) | |
| TT | 13/10 | 0.387 | 1.619 (0.543–4.823) | |
| TT + CT vs. CC | 0.732 | 0.899 (0.490–1.651) | ||
| TT vs. CT + CC | 0.179 | 1.944 (0.737–5.125) | ||
| No | CC | 61/82 | ||
| CT | 60/101 | 0.851 | 1.049 (0.635–1.735) | |
| TT | 17/30 | 0.914 | 1.042 (0.492–2.210) | |
| TT + CT vs. CC | 0.840 | 1.050 (0.652–1.693) | ||
| TT vs. CT + CC | 0.974 | 1.011 (0.505–2.025) | ||
| Drinking | n = 228 vs. 335 | |||
| Yes | CC | 30/35 | ||
| CT | 34/46 | 0.570 | 0.820 (0.413–1.626) | |
| TT | 10/5 | 0.354 | 1.826 (0.511–6.529) | |
| TT + CT vs. CC | 0.825 | 0.928 (0.478–1.802) | ||
| TT vs. CT + CC | 0.178 | 2.238 (0.693–7.226) | ||
| No | CC | 68/94 | ||
| CT | 66/120 | 0.947 | 0.984 (0.611–1.585) | |
| TT | 20/35 | 0.892 | 1.050 (0.519–2.125) | |
| TT + CT vs. CC | 0.965 | 1.010 (0.641–1.591) | ||
| TT vs. CT + CC | 0.879 | 1.052 (0.549–2.014) | ||
| rs3759571 | ||||
| Gender# | n = 578 vs. 584 | |||
| Male | GG | 163/172 | ||
| GA | 201/201 | 0.751 | 1.052 (0.769–1.438) | |
| AA | 47/56 | 0.844 | 0.953 (0.592–1.534) | |
| AA + GA vs. GG | 0.822 | 1.035 (0.768–1.395) | ||
| AA vs. GA + GG | 0.778 | 0.938 (0.601–1.463) | ||
| Female | GG | 76/58 | ||
| GA | 67/77 | 0.128 | 0.678 (0.411–1.119) | |
| AA | 24/20 | 0.848 | 0.930 (0.446–1.941) | |
| AA + GA vs. GG | 0.218 | 0.743 (0.462–1.193) | ||
| AA vs. GA + GG | 0.620 | 1.188 (0.601–2.349) | ||
| Age (years) | n = 578 vs. 584 | |||
| ≥60 | GG | 113/86 | ||
| GA | 141/121 | 0.408 | 0.841 (0.557–1.268) | |
| AA | 28/31 | 0.353 | 0.735 (0.385–1.406) | |
| AA + GA vs. GG | 0.324 | 0.819 (0.551–1.218) | ||
| AA vs. GA + GG | 0.528 | 0.823 (0.449–1.507) | ||
| <60 | GG | 126/144 | ||
| GA | 127/157 | 0.771 | 0.949 (0.667–1.349) | |
| AA | 43/45 | 0.663 | 1.122 (0.668–1.884) | |
| AA + GA vs. GG | 0.966 | 0.993 (0.712–1.385) | ||
| AA vs. GA + GG | 0.491 | 1.183 (0.733–1.907) | ||
| H. pylori infection# | n = 578 vs. 584 | |||
| Positive | GG | 119/46 | ||
| GA | 140/44 | 0.510 | 1.178 (0.723–1.919) | |
| AA | 34/8 | 0.249 | 1.656 (0.703–3.903) | |
| AA + GA vs. GG | 0.338 | 1.256 (0.788–2.003) | ||
| AA vs. GA + GG | 0.306 | 1.530 (0.678–3.451) | ||
| Negative | GG | 120/184 | ||
| GA | 128/234 | 0.279 | 0.840 (0.613–1.152) | |
| AA | 37/68 | 0.425 | 0.828 (0.521–1.317) | |
| AA + GA vs. GG | 0.253 | 0.840 (0.623–1.132) | ||
| AA vs. GA + GG | 0.676 | 0.912 (0.593–1.403) | ||
| Smoking | n = 236 vs. 350 | |||
| Yes | GG | 42/50 | ||
| GA | 41/62 | 0.659 | 0.869 (0.465–1.624) | |
| AA | 14/15 | 0.730 | 1.183 (0.456–3.070) | |
| AA + GA vs. GG | 0.803 | 0.927 (0.511–1.680) | ||
| AA vs. GA + GG | 0.625 | 1.243 (0.519–2.978) | ||
| No | GG | 62/88 | ||
| GA | 63/107 | 0.746 | 0.922 (0.565–1.506) | |
| AA | 14/28 | 0.564 | 0.798 (0.371–1.716) | |
| AA + GA vs. GG | 0.666 | 0.902 (0.565–1.440) | ||
| AA vs. GA + GG | 0.706 | 0.867 (0.413–1.819) | ||
| Drinking | n = 236 vs. 350 | |||
| Yes | GG | 29/38 | ||
| GA | 38/46 | 0.736 | 1.125 (0.568–2.227) | |
| AA | 10/5 | 0.200 | 2.225 (0.655–7.561) | |
| AA + GA vs. GG | 0.535 | 1.230 (0.640–2.365) | ||
| AA vs. GA + GG | 0.236 | 2.039 (0.628–6.625) | ||
| No | GG | 75/100 | ||
| GA | 66/121 | 0.261 | 0.765 (0.480–1.220) | |
| AA | 18/38 | 0.244 | 0.664 (0.334–1.321) | |
| AA + GA vs. GG | 0.194 | 0.746 (0.479–1.161) | ||
| AA vs. GA + GG | 0.481 | 0.788 (0.407–1.527) |
*
Adjusted for gender, age, and H. pylori infection.
#
Adjusted for two other factors besides self. Bold Values indicate the data is statistically significant differences (P < 0.05).