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. Author manuscript; available in PMC: 2020 Jul 31.
Published in final edited form as: Vet Comp Oncol. 2010 Dec 14;9(3):207–218. doi: 10.1111/j.1476-5829.2010.00249.x

Figure 2.

Figure 2.

Canine osteosarcoma (OS) cell lines are tumorigenic in mice and yield tumours with histological descriptors characteristic of OS. (A,D,G) Primary tumour growth patterns of canine OS cells in Beige-SCID mice. Each line represents growth of an individual mouse. H&E staining (B,E,H) of primary tumour resulting from orthotopic injection of KOS-001, KOS-003 and KOS-004 cell lines showed streams of closely packed spindloid tumour cells within a fibrous stroma and small islands of osteoid (see arrow heads) are scattered between the tumour cells. (C,F,I) Primary tumours of KOS-001, KOS-003 and KOS-004 cell lines showed positive ALP staining. Scale bar = 100 μm.