Table 1.
Comparison of Demographics and Treatment of WNT MB, Stratified by Relapse
| No Relapse | Relapse | p Value | |
|---|---|---|---|
| Age years (median + IQR) | 10 (8–14.2) | 11 (9.75–14.35) | 0.45 |
| Gender | 0.09 | ||
| Male | 27 | 9 | |
| Female | 50 | 6 | |
| M-status | 0.65 | ||
| M0 | 65 | 13 | |
| M+ | 7 | 2 | |
| Extent of Resection | 0.34 | ||
| GTR | 64 | 15 | |
| STR | 8 | 0 | |
| Craniospinal Irradiation Dose | 1 | ||
| ≤23.4 Gy | 37 | 8 | |
| ≥23.4 Gya | 35 | 7 | |
| Chemotherapy | 0.032 | ||
| No chemotherapy or older protocols | 18 | 6 | |
| CCNU-based | 26 | 8 | |
| Cyclophosphamide/ifosfamide-based (>12 g/m2) | 30 | 1 | |
| Chromosome 6 | 0.68 | ||
| Balanced chromosome 6 | 10 | 1 | |
| Monosomy 6 | 66 | 14 | |
| Chromosome 17p | 0.19 | ||
| 17p balanced | 64 | 12 | |
| 17p loss | 6 | 3 |
GTR, gross total resection; STR, subtotal resection with residual >1.5 cm2. Cyclophosphamide/ifosfamide includes ICE regimens. CCNU-based includes treatment according to ACNS0331. Chromosomes 6 and 17 are arm-level losses. The p values are from a Fisher’s exact test, except age at diagnosis was determined using a Mann-Whitney U test. Bold p-values represent values below 0.05.
a
≥23.4-Gy craniospinal irradiation (CSI) includes 3 patients with 25-Gy CSI and 2 patients with 30.6-Gy CSI.