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. 2020 Jul 29;8(2):e000970. doi: 10.1136/jitc-2020-000970

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Tumor mutation burden and T-cell receptor (TCR) repertoire of pretreatment and postceritinib-resistant tumor. (A) Tumor mutation burden (TMB) was measured by whole exome sequencing. (P value: NS, non-significant). (B) CDR3 length of TCR-beta were analyzed by MixCR and TcR analysis packages. The black arrow represents the top frequency of CDR3 length. (C) The TCR-beta V and J usages were analyzed by principal component analysis (PCA) with pretreatment and postceritinib treatment groups. The major principal components 1 and 2 were used as PC1 (X-axis) and PC2 (Y-axis) in the PCA plot.