Table 4.

Multivariable analysis of associations between total and detectable serum estradiol and other variables

	β (95% CI)	P for β	R2
Models for ln total E2, n = 5190 (backward elimination)
ln E1	0.432 (0.398 to 0.466)	< .001	0.211
ln T	0.115 (0.087 to 0.142)	< .001
ln DHEA	–0.026 (–0.053 to 0.001)	.057
Age, y	–0.007 (–0.011 to –0.003)	< .001
BMI, kg/m2	0.010 (0.007 to 0.013)	< .001
After removal of ln DHEA
ln E1	0.416 (0.383 to 0.448)	< .001	0.210
ln T	0.107 (0.081 to 0.134)	< .001
Age, y	–0.006 (–0.010 to –0.003)	< .001
BMI, kg/m2	0.010 (0.007 to 0.013)	< .001
Models for ln dE2, n = 1774 (backward elimination)
ln E1	0.368 (0.307 to 0.428)	< .001	0.164
ln T	0.196 (0.145 to 0.246)	< .001
ln DHEA	–0.035 (–0.085 to 0.015)	.167
Age, y	–0.004 (–0.011 to 0.003)	.301
BMI, kg/m2	0.003 (–0.003 to 0.008)	.334
After removal of BMI
ln E1	0.373 (0.314 to 0.432)	< .001	0.164
ln T	0.198 (0.147 to 0.248)	< .001
ln DHEA	–0.038 (–0.087 to 0.012)	.134
Age, y	–0.004 (–0.011 to 0.003)	.241
After removal of age
ln E1	0.371 (0.312 to 0.430)	< .001	0.164
ln T	0.194 (0.145 to 0.244)	< .001
ln DHEA	–0.034 (–0.083 to 0.015)	.175
After removal of ln DHEA
ln E1	0.360 (0.303 to 0.417)	< .001	0.163
ln T	0.180 (0.135 to 0.226)	< .001

Abbreviations: BMI, body mass index; dE₂, detectable estradiol; E₁, estrone; E₂, estradiol; DHEA, dehydroepiandrosterone; ln, log-transformed; T, testosterone.