TABLE 1.
Baseline participant characteristics and vaginal microbiome composition overall and stratified by community state typea
| Characteristic | No. of participants (%) with characteristic or specified value |
|||
|---|---|---|---|---|
| Total (n = 171) | CST I (n = 14) | CST-III (n = 77) | CST-IVb (n = 77) | |
| Median age in yrs (IQR) | 22 (20–25) | 24.5 (19–28) | 23 (20–25) | 22 (20–25) |
| HIV status | ||||
| Negative | 152 (89.9) | 14 (100) | 70 (92.1) | 65 (85.5) |
| Positive | 17 (10.1) | 6 (7.9) | 11 (14.5) | |
| Missing | 2 | 1 | 1 | |
| HSV-2 status | ||||
| Negative | 81 (47.4) | 12 (85.7) | 39 (50.6) | 28 (36.4) |
| Positive | 90 (52.6) | 2 (14.3) | 38 (49.4) | 49 (63.6) |
| Circumcised male sex partner | 91 (53.2) | 6 (42.9) | 43 (55.8) | 40 (52.0) |
| BV (Nugent score of 7 to 10) at baseline | 37 (21.6) | 0 (0) | 4 (5.2) | 33 (42.9) |
| Proportion of visits with BV over follow-up | ||||
| 0% | 89 (52.1) | 14 (100) | 49 (63.6) | 25 (32.5) |
| 25% | 22 (12.9) | 10 (13.0) | 11 (14.3) | |
| 25%−50% | 33 (20.2) | 11 (14.3) | 21 (27.3) | |
| 50%−75% | 19 (11.1) | 7 (9.1) | 12 (15.5) | |
| 100% | 8 (4.7) | 8 (10.4) | ||
| Presence of L. crispatus at baseline | 42 (24.6) | 14 (100) | 22 (28.6) | 6 (7.8) |
| Mean RA of L. crispatus if present (SD) | 28.2 (35.3) | 72.5 (21.6) | 7.71 (13.0) | 0.21 (0.34) |
| Presence of L. iners at baseline | 142 (83.0) | 5 (35.7) | 77 (100) | 58 (75.3) |
| Mean RA of L. iners if present (SD) | 44.8 (42.4) | 1.84 (3.24) | 80.3 (23.2) | 2.99 (5.11) |
| Presence of G. vaginalis at baseline | 129 (75.4) | 7 (50.0) | 46 (59.7) | 73 (94.8) |
| Mean RA of G. vaginalis if present (SD) | 23.1 (24.8) | 20.9 (15.0) | 6.81 (10.8) | 33.7 (26.7) |
| Median Shannon diversity index (IQR) | 0.94 (0.30–1.82) | 0.80 (0.33–0.98) | 0.34 (0.16–0.83) | 1.84 (1.20–2.17) |
a
CST, community state type; IQR, interquartile range; BV, bacterial vaginosis; RA, relative abundance; SD, standard deviation.
b
CST-IV combined subtypes A (n = 9), B (n = 62), and C (n = 6). Statistics stratified by CST are not reported for three observations (two for CST-II and one for CST-V).