TABLE 4.
Results of disease/phenotype analysis: top phenotypes associated with vaginal microbiome traits
| Trait and phenotype | Observed no. of genes/total no. of genes |
P value | Adjusted P valuea |
|---|---|---|---|
| L. crispatus | |||
| Bacterial infections | 23/260 | 9.25E−06 | 1.10E−02 |
| Meckel syndrome (MKS) | 17/164 | 1.78E−05 | 1.37E−02 |
| Hypertension, pulmonary | 15/137 | 2.88E−05 | 1.37E−02 |
| Varicose veins | 11/79 | 3.64E−05 | 1.45E−02 |
| Gram-positive bacterial infections | 17/181 | 6.29E−05 | 2.15E−02 |
| L. iners | |||
| Autosomal dominant inheritance | 72/1403 | 3.17E−05 | 1.78E−02 |
| Growth abnormality | 88/1822 | 3.89E−05 | 1.91E−02 |
| Abnormality of the cardiovascular system | 86/1796 | 6.49E−05 | 2.83E−02 |
| Aplasia/hypoplasia involving the vertebral column | 8/55 | 3.08E−04 | 8.05E−02 |
| Abnormality of hair density | 20/267 | 3.35E−04 | 8.05E−02 |
| G. vaginalis | |||
| Pancreatic neoplasm | 11/88 | 6.51E−05 | 8.52E−02 |
| Carcinoma, pancreatic ductal | 13/139 | 2.95E−04 | 2.44E−01 |
| Pancreatic neoplasms | 19/281 | 9.08E−04 | 3.56E−01 |
| Neoplasm of the endocrine system | 9/89 | 1.42E−03 | 4.11E−01 |
| Thyroid neoplasms | 13/165 | 1.48E−03 | 4.11E−01 |
| Shannon diversity index | |||
| Abnormality of the female genitalia | 33/505 | 1.31E−05 | 3.71E−02 |
| Abnormality of female internal genitalia | 29/444 | 4.38E−05 | 5.12E−02 |
| Abnormal internal genitalia | 30/473 | 5.57E−05 | 5.12E−02 |
| Abnormality of the uterus | 15/176 | 1.92E−04 | 6.52E−02 |
| Abnormality of the ovary | 16/196 | 1.96E−04 | 6.52E−02 |
| Community state type | |||
| Serotonin syndrome | 23/134 | 1.18E−11 | 4.39E−08 |
| Abnormality of the integument | 99/1920 | 5.16E−08 | 1.01E−04 |
| Autosomal dominant inheritance | 74/1403 | 1.33E−06 | 1.50E−03 |
| Prader-Willi syndrome | 20/195 | 1.70E−06 | 1.50E−03 |
| Abnormality of the skin | 80/1572 | 1.92E−06 | 1.50E−03 |
a
P values are Benjamini-Hochberg adjusted.