Table 1. Group designation, animal identification, and dose levels.
Group Number | N (M/F) | Animal Identification (M/F) | Test Article | Test Article Dose Level | Day of Termination | |
---|---|---|---|---|---|---|
1 | 5/5 | 01–05 | 06–10 | Vehicle Control | 0 mg/kg | 2 |
2 | 5/5 | 11–15* | 16–20 | Vehicle Control | 0 mg/kg | 14 |
3 | 5/5 | 21–25 | 26–30* | hEGFRvIII-CD3 bi-scFv | 7.5 mg/kg | 2 |
4 | 5/5 | 31–35 | 36–40 | hEGFRvIII-CD3 bi-scFv | 7.5 mg/kg | 14 |
*At dosing, animal 41 replaced animal 11 and animal 42 replaced animal 29.