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. 2020 Jul 31;15(7):e0236830. doi: 10.1371/journal.pone.0236830

Table 2. Prescribed medications use of the population according to ATC system.

Characteristics Triad combination (n = 181) N (%) Non-triad combination (n = 235) N (%) P value
Total number of medications 1577 (100) 1450 (100)
No. of prescribed medications/person, median (IQR) 8 (6, 10) 6 (4, 8) <0.001+
Prescribed medications according to ATC classes and codes
A02 Drugs for acid related disorders 70 (38.7) 65 (27.7) 0.017*
A06 Drugs for constipation 77 (42.5) 97 (41.3) 0.795*
A10 Drug used in diabetes 34 (18.8) 24 (10.2) 0.012*
A11 Vitamins 69 (38.1) 87 (37.0) 0.818*
A12 Mineral supplements 75 (41.4) 68 (28.9) 0.008*
B01 Antithrombotic agents 144 (79.6) 174 (74.0) 0.189*
C01 Cardiac therapy 51 (28.2) 21 (8.9) < 0.001*
C02 Antihypertensives 11 (6.1) 5 (2.1) 0.038*
C03 Diuretics 54 (29.8) 35 (14.9) <0.001*
C07 Beta blocking agents 66 (36.5) 62 (26.4) 0.027*
C08 Calcium channel blockers 32 (17.7) 42 (17.9) 0.959*
C09 Agents acting on the renin- angiotensin system 84 (46.4) 80 (34.0) 0.011*
C10 Lipid modifying agents 76 (42.0) 70 (29.8) 0.010*
D Dermatologicals 6 (3.3) 13 (9.3) 0.035*
H02 Corticosteroids 15 (8.3) 18 (7.7) 0.060*
Prescribed medications according to ATC classes and codes
H03 Thyroid therapy 29 (16.0) 21 (8.9) 0.028*
J01 Antibacterial drugs 44 (24.3) 44 (18.7) 0.167*
N02 Analgesics 77 (42.5) 80 (34.0) 0.076*
N03 Antiepileptics 19 (10.5) 10 (4.3) 0.013*
N05 Psycholeptics 97 (53.6) 45 (19.1) < 0.001*
    N05A Antipsychotics 82 (45.3) 37 (15.7) < 0.001*
    N05B-N05C Anxiolytics, sedatives and hypnotics 31 (17.1) 12 (5.1) < 0.001*
N06 Psychoanaleptics 74 (40.9) 49 (20.9) < 0.001*
    N06A Antidepressants 65 (35.9) 37 (15.7) < 0.001*
    N06D Anti-dementia drugs 20 (11.0) 16 (6.8) 0.127*
R03 Drugs for obstructive airway diseases 19 (10.5) 22 (9.4) 0.700*

Data are presented as n (%), or median (interquartile range).

* Chi-square test

+ Mann–Whitney U test.

Abbreviations: IQR, interquartile range; ATC, anatomical therapeutic chemical.