Top: MI of the non-corrected (N.C), registration corrected (R.C.), legacy synthetic-distortion (S.D) and proposed synthetic correction (Syn.C.) b0 images with the structural T1 image. A higher value suggests a geometry more similar to the undistorted T1. MIddle: MI of the N.C, R.C., S.D, and Syn.C. b0 with state-of-the art topup distortion correction results. A higher value indicates geometry/contrast more similar to the goldstandard. Bottom: MSE of the N.C., R.C., S.D, and Syn.C., b0 with state-of-the art topup distortion correction results. A lower value indicates structure and image intensities more similar to the topup results. For both, solid and dashed lines indicate mean and median values, respectively. Each contains 15 datapoints, from 5 HCP subjects (blue), 5 Vanderbilt subjects (black), and 5 BLSA subjects (red).