Table 1.
Nucleoporin functions.
| NPC region | Protein Symbol | Description | Function | References |
|---|---|---|---|---|
| Cytoplasmic | NUP358 | Nucleoporin 358; RAN binding protein 2 (RANBP2) | SUMOylation enhancer | [60–62] |
| NUP214 | Nucleoporin 214 | Regulation of protein activity | [63] | |
| NUP88 | Nucleoporin 88 | Chromatin binding | [20] | |
| ALADIN | ALADIN/ADRACALIN | Spindle formation and chromosomal alignment | [64] | |
| NUP42 | Nucleoporin 42; NUPL2; HCG1; NLP1/2 | RNA export/enhances RNA helicase activity | [65] | |
| NUP98* | Nucleoporin 98* | Chromatin binding, mRNA export | [20, 66, 67] | |
| Y-complex | NUP37 | Nucleoporin 37 | NPC stabilization and assembly during mitosis | [68, 69] |
| NUP43 | Nucleoporin 43 | NPC assembly during mitosis | [70, 71] | |
| NUP85 | Nucleoporin 85 | NPC assembly during mitosis | [70, 71] | |
| NUP96* | Nucleoporin 96* | mRNA export, role in immune response mediated by interferons | [72–75] | |
| NUP107 | Nucleoporin 107 | NPC assembly during mitosis | [70, 71] | |
| NUP133 | Nucleoporin 133 | mRNA export, NPC assembly during mitosis | [71, 76] | |
| NUP160 | Nucleoporin 160 | mRNA export, NPC assembly during mitosis | [70, 71, 76] | |
| SEC13 | SEC13 Homolog, Nuclear Pore and COPII Complex Component | NPC assembly | [77] | |
| SEH1L | SEH1 Like Nucleoporin | Activation of mTOR signaling, NPC assembly during mitosis | [70, 78] | |
| ELYS | AHCTF1 gene, AT-Hook Containing Transcription Factor 1 | NPC stabilization and assembly during mitosis | [68] | |
| Inner Ring | NUP35 | Nucleoporin 53 | Post-transcriptional regulation; oocyte meiotic spindle formation | [79, 80] |
| NUP93 | Nucleoporin 93 | Gene repression | [47, 81] | |
| NUP155 | Nucleoporin 155 | Chromatin binding/tethering and accessibility | [43, 51, 82, 83] | |
| NUP188 | Nucleoporin 188 | Gene repression | [81] | |
| NUP205 | Nucleoporin 205 | Gene repression | [81] | |
| Central channel | NUP45/58 | Nucleoporin 58; NUPL1 | Centrosome regulation | [84] |
| NUP54 | Nucleoporin 54 | Double strand break repair | [85] | |
| NUP62 | Nucleoporin 62 | Imprinted domain regulation; chromatin tethering; centrosome homeostasis | [51, 86, 87] | |
| Transmembrane | POM121 | Nuclear pore membrane protein 121 kDa | Transcriptional regulation; NPC assembly | [88–90] |
| NUP210/GP210 | Nuclear pore membrane glycoprotein 210 | NE/ER homeostasis; gene regulation | [91–93] | |
| NDC1/TMEM48 | Nuclear Division Cycle 1 homolog; Transmembrane protein 48 | NPC assembly | [94] | |
| Nucleoplasmic | NUP50 | Nucleoporin 50 | Chromatin binding | [19, 92] |
| NUP153 | Nucleoporin 153 | Chromatin binding, RNA export | [3, 44, 45, 92, 95] | |
| TPR | Translocated Promoter Region | Heterochromatin exclusion | [48] | |
Provided here are functions/biological contexts documented for NUPs. In bold are NUPs with reported high mobility (NUP98, NUP210, NUP50, and NUP153) that can be found distal from the NPC within the nuclear envelope and/or the nucleoplasm.
*
NUP96 and NUP98 are translated from the same transcript, and post-translational cleavage of the protein product generates both.