Table 2.

List of nucleoporins associated with cardiovascular disorders. Each nucleoporin is depicted with their respective gene and/or protein alteration associated with the respective cardiopathology and related reference.

Cardiopathology	Gene Name	Description	Gene/protein alteration	Reference
Arrhythmias	NUP155	Nucleoporin 155	missense mutation (R391H, L503F)	[5, 42, 102]
	NUP107	Nucleoporin 107	disrupted export of scn5a	[103]
	NUP37	Nucleoporin 37	nonsense mutation	[2]
	NUP153	Nucleoporin 153	protein overexpression	[3]
Dilated Cardiomyopathy	NDC1	NDC1 transmembrane nucleoporin	protein overexpression	[4]
	NUP160	Nucleoporin 160	protein overexpression	[4]
	NUP93	Nucleoporin 93	protein overexpression	[4]
	NUP153	Nucleoporin 153	protein overexpression	[3, 4, 104]
	NUP358/RANBP2	RAN binding protein 2	gene down regulation	[104]
Ischemic Cardiomyopathy	NDC1	NDC1 transmembrane nucleoporin	protein overexpression	[4]
	NUP160	Nucleoporin 160	protein overexpression	[4]
	NUP153	Nucleoporin 153	protein overexpression	[3, 4, 104]
	NUP358/RANBP2	RAN binding protein 2	gene down regulation	[104]
	NUP62	Nucleoporin 62	protein changes	[105, 106]
Congestive Heart Failure	NUP85/FROUNT	Nucleoporin 85	protein overexpression and cytosolic mislocalization	[107]
Valve, vascular disorders	NUP188	Nucleoporin 188	Splice-donor site mutation, gene duplication	[2, 96]
	NUP43	Nucleoporin 43	nonsense mutation	[2]
Heterotaxy/Situs inversus	NUP205	Nucleoporin 205	missense mutation	[99]
	NUP210	Nucleoporin 210	missense mutation	[99]
	NUP188	Nucleoporin 188	gene duplication	[97]