Table 1.
Clinical Characteristics of Neonatal Patients Infected or Colonized with CZA-Resistant and CZA-Sensitive CRKP Isolates
| Clinical Characteristics | No of Patients (%) | P value | |
|---|---|---|---|
| CZA-Resistant CRKP(n=10) | CZA-Sensitive CRKP(n=33) | ||
| Age (median, days) | 30(12.75–30.00) | 27(13.00–30.00) | 0.58 |
| Sex, male | 6(60.00) | 16(48.48) | 0.78 |
| Birth weight(g) | 2092 | 1514 | 0.09 |
| Very low birth weight | 5(50.00) | 17(51.52) | 1 |
| Gestational age (median, weeks) | 32.30(28.98–39.78) | 30.10(29.35–33.00) | 0.15 |
| Premature | 6(60.00) | 31(93.94) | 0.02 |
| Vaginal birth/C-section, C-section | 9(90.00) | 17(51.52) | 0.07 |
| Length from admission to CRKP (days) | 2.50(2.00–10.25) | 2.00(2.00–2.00) | 0.63 |
| Length of hospitalization (days) | 19.50(14.25–36.50) | 23.00(15.00–41.50) | 0.39 |
| Colonization | 1(10.00) | 5(15.15) | 1 |
| Infection | 9(90.00) | 28(84.85) | |
| Source of isolates | |||
| Respiratory | 10(10.00) | 26(78.79) | 0.27 |
| Blood | 0(0.00) | 7(21.21) | |
| Antibiotic exposure | |||
| Carbapenems | 4(40.00) | 21(63.64) | 0.33 |
| β-lactam/β-lactamase inhibitor combinations | 6(60.00) | 18(54.55) | 1 |
| β-lactam antibiotics | 3(30.00) | 19(57.58) | 0.24 |
| Invasive procedures | |||
| Mechanical ventilation | 6(60.00) | 17(51.52) | 0.91 |
| Surgery | 2(20.00) | 1(3.03) | 0.12 |
| Disease | |||
| Pneumonia | 7(70.00) | 30(90.91) | 0.12 |
| Septicemia | 4(40.00) | 18(54.55) | 0.66 |
| Underlying conditions | |||
| Hematological disease | 8(80.00) | 22(66.67) | 0.68 |
| Neurological diseases | 6(60.00) | 16(48.48) | 0.78 |
| Cardiovascular disease | 3(30.00) | 5(15.15) | 0.55 |
| Respiratory dysplasia | 4(40.00) | 10(30.30) | 0.85 |
| Retinopathy of prematurity | 3(30.00) | 5(15.15) | 0.55 |
| Digestive diseases | 5(50.00) | 10(30.30) | 1 |