Table 3.
Antimicrobial Activities of CZA-Resistant and CZA-Sensitive CRKP Isolates
| Antibiotics | MIC Range | CZA-Resistant CRKP(n=10) | CZA-Sensitive CRKP(n=33) | P value (CZA-Resistant R %/CZA-Sensitive R%) | ||||
|---|---|---|---|---|---|---|---|---|
| MIC50 | MIC90 | R (%) | MIC50 | MIC90 | R (%) | |||
| CZA | ≤0.25/4->32/4 | >32/4 | >32/4 | 100 | 2/4 | 2/4 | 0 | – |
| CZT | ≤0.5/4->64/4 | >64/4 | >64/4 | 100 | >64/4 | >64/4 | 100 | – |
| TZP | ≤4/4->256/4 | >256/4 | >256/4 | 100 | >256/4 | >256/4 | 100 | – |
| CSL | ≤1/0.5->128/64 | >128/4 | >128/4 | 100 | >128/4 | >128/4 | 100 | – |
| PIP | ≤2->256 | >256 | >256 | 100 | >256 | >256 | 100 | – |
| CZO | ≤0.5->32 | >32 | >32 | 100 | >32 | >32 | 100 | – |
| CMZ | ≤0.5->64 | >64 | >64 | 100 | >64 | >64 | 100 | – |
| CXM | ≤1->64 | >64 | >64 | 100 | >64 | >64 | 100 | – |
| CAZ | ≤0.25->32 | >32 | >32 | 100 | >32 | >32 | 100 | – |
| CRO | ≤0.25->32 | >32 | >32 | 100 | >32 | >32 | 100 | – |
| FEP | ≤16->32 | >32 | >32 | 100 | >32 | >32 | 100 | – |
| IPM | ≤0.12->16 | >16 | >16 | 100 | >16 | >16 | 100 | – |
| MEM | ≤0.12->16 | >16 | >16 | 100 | >16 | >16 | 100 | – |
| ETP | ≤0.25->32 | >32 | >32 | 100 | >32 | >32 | 100 | – |
| AMK | ≤1->128 | ≤1 | >128 | 30 | >128 | >128 | 87.8 | 0.001 |
| GEN | ≤1->128 | 64 | >128 | 90 | >128 | >128 | 100 | 0.233 |
| NIT | ≤2->128 | 64 | >128 | 50 | >128 | >128 | 100 | 0 |
| SXT | ≤0.25/4.75->32/608 | >32/608 | >32/608 | 70 | ≤0.25/4.75 | >32/608 | 87.8 | 0.394 |
| ATM | ≤1->128 | >128 | >128 | 100 | >128 | >128 | 100 | – |
| LVX | ≤0.12->16 | 1 | >16 | 40 | >16 | >16 | 100 | 0 |
| CIP | ≤0.06->8 | 1 | >8 | 70 | >8 | >8 | 100 | 0.01 |
| DOX | ≤1->128 | 32 | 64 | 80 | 4 | 16 | 33.3 | 0.025 |
| POL | ≤0.25->16 | 0.5 | 1 | 0 | 0.5 | 1 | 0 | – |
| TGC | ≤0.12->16 | 0.5 | 1 | 0 | 1 | 1 | 0 | – |