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. 2020 Jul 27;15:21–29. doi: 10.2147/CE.S203634

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© 2020 Lorusso et al.

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Post hoc analysis on carboplatin-based regimes. (A) Histograms showing the effect of a CINV prophylaxis with or without NK₁-RA on the first chemotherapy cycle. Adapted from Critical Reviews in Oncology/Hematology, Vol 124, Di Maio M, Baratelli C, Bironzo P, et al, Efficacy of neurokinin-1 Receptor Antagonists in the Prevention of Chemotherapy-Induced Nausea and Vomiting in Patients Receiving Carboplatin-Based Chemotherapy: A Systematic Review and Meta-Analysis, Pages No. 21-28, Copyright (2018), with permission from Elsevier.44 (B) Histograms showing the CR rate on patients treated with NEPA+DEX compared with patients treated with APR+PALO+DEX. Adapted by permission from Springer Nature Customer Service Centre GmbH: Springer Nature, Supportive Care in Cancer. Efficacy Benefit of an NK1 Receptor Antagonist (NK1RA) in Patients Receiving Carboplatin: Supportive Evidence With NEPA (A Fixed Combination of the NK1 RA, Netupitant, and Palonosetron) and Aprepitant Regimens, Jordan K, Gralla R, Rizzi G, et al, [COPYRIGHT] (2016).45

Abbreviations: CINV, chemotherapy-induced nausea and vomiting; CR, complete response; NEPA, netupitant-palonosetron; 5HT3-RA, serotonin type 3 receptor antagonist; NK1-RA, neurokinin type 1 receptor antagonist; DEX, dexamethasone; APR, aprepitant; PALO, palonosetron.