Table 1.

Comparison of Different CINV Prophylactic Treatments in Randomized Pivotal Studies in Cisplatin-Based Regimes

Study and Study Arms	Number of Randomized Patients per Arm	Cancer Type	Complete Response	No Significant Nausea
Poli Bigelli et al Cancer. 200339 APR+OND+DEX OND+DEX	260 263	Lung 36%; Urogenital 39%; Head and neck 8%; other a%	Acute: 82.8% vs 68.4% * Delayed: 67.7% vs 46.8% * Overall: 62.7% vs 43.3% *	Acute: not performed Delayed: 73% vs 65% Overall: 71% vs 64%
Hesketh et al J Clin Oncol. 200340 APR+OND+DEX OND+DEX	260 261	Lung 42%; Urogenital 23%; other 35%	Acute: 89.2% vs 78.1% * Delayed: 75.4% vs 55.8% * Overall: 72.7% vs 52.3% *	Acute: 90.6% vs 86.5% Delayed: 75.3% vs 68.5% Overall: 73.2% vs 66.0%
Grunberg et al J Clin Oncol. 201141 FOS+OND+DEX APR+OND+DEX	1147 1175	Lung 47%; GI 21%; Urogenital 15%; other 17%	Acute: 89.0% vs 88.0% Delayed: 74.3% vs 74.2% Overall: 71.9% vs 72.3%	Acute: not performed Delayed: not performed Overall: 70.1% vs 70.4%
Hesketh et al Ann Oncol. 201433 NEPA+DEX PAL+DEX	135 136	Urogenital 29%; Lung 28%; Head and neck 21%; GI 12%; other 10%	Acute: 98.5% vs 89.7% * Delayed: 90.4% vs 80.1% * Overall: 89.6% vs 76.5% *	Acute: 98.5% vs 93.4% * Delayed: 90.4% vs 80.9% * Overall: 89.6% vs 79.4% *
Rapoport et al Lancet Oncol. 2015 (HEC-1)15 ROL+GRA+DEX GRA+DEX	264 262	Lung 38%; Head and neck 21%; Urogenital 9%; other 32%	Acute: 84% vs 74% * Delayed: 73% vs 58% * Overall: 70% vs 56% *	Acute: 86% vs 79% * Delayed: 73% vs 65% * Overall: 72% vs 63% *
Rapoport et al Lancet Oncol. 2015 (HEC-2)15 ROL+GRA+DEX GRA+DEX	271 273	Lung 49%; Head and neck 16%; GI 9%; other 26%	Acute: 83% vs 79% Delayed: 70% vs 62% * Overall: 68% vs 60%	Acute: 90% vs 86% Delayed: 75% vs 69% Overall: 73% vs 68%

Note: *Results are statistically significant.

Abbreviations: CINV, chemotherapy-induced nausea and vomiting; APR, aprepitant; FOS, fosaprepitant; ROL, rolapitant; OND, ondansetron; GRA, granisetron; PALO, palonosetron; NEPA, netupitant-palonosetron; DEX, dexamethasone; GI, gastrointestinal.