Table 3. Functions of genes with significant lipid-gene transcriptome associations.

Biological Pathways	Gene Transcripts*	Relevance to the CNS
Inflammation
Innate immunity	↓LILRB3, ↓MGAM
Adaptive immune response	↓LILRA6
Host Defense	↓FPR1, ↓TRIM51	FPR1 found in neural glial cells, astrocytes and neuroblastoma (Cussell et al., 2019).
Allergic Response	↓ADAM8, ↓HDC, ↓CPA3	ADAM8 may regulate cell adhesion during neurodegeneration (Schlomann et al., 2000). HDC as a histidine decarboxylase, produces histamine, which in the CNS is a neurotransmitter (Yoshikawa et al., 2014).
Class I MHC antigen binding	↓LILRA6, ↓LILRB3
B-Cell response/receptor signalling	↓GAB2, ↓LILRB3, ↓PRKCD	GAB2 is associated with Alzheimer's disease. By activating PI3K, increases amyloid production and microglia-mediated inflammation. Several GAB2 SNPs are associated with late-onset Alzheimer’s disease (Chen et al., 2018).
Mast Cell Degranulation	↓CPA3, ↓HDC,
Vasoactive Actions
Regulation of vasoactive peptides (e.g., endothelin, angiotensin 1, snake toxins, etc)	↓GATA2, ↓CPA3,
Epithelial Cell Integrity	↓KRT23, ↓PRKCD
Cell Adhesion	↓APMAP	APMAP supresses brain Aβ production (Mosser et al., 2015).
DNA Regulation	↑ RPSA, ↑ SNORA62, ↑ SNHG1
Vesicle/Endosome Regulation/Transport	↑ VAMP8, ↓REPS2, ↓SLC45A3	SLC45A3 regulates oligodendrocyte differentiation (Shin et al., 2012).
Pseudogenes/non-protein coding	↓S100A11P1, ↓RPSAP15, ↑ RP11-179G5.1, ↑ RP11-350G8.3, ↑ RPL35P5, ↑ RPL4P2, ↑ RPS10P14, ↑ RPSAP15, ↑ RPSAP58, ↑ SNHG1, ↑ SNORA62	Regulatory roles. Gene silencing, affects mRNA stability.