Table 3.
The Effect of Compound 4 (1 mg/kg) on the IC50 Values of Molecular Targeting Agents on MHCC97-H Cells’ Subcutaneous Tumor Volumes, Tumor Weights or the Intrahepatic Nodule Areas
| Agents | Groups | Tumor Volumes | Tumor Weights |
|---|---|---|---|
| IC50 Values (mg/kg) | |||
| Sorafenib | Solvent control | 1.30±0.48 | 1.57±0.41 |
| Compound 4 | 0.17±0.03 | 0.15±0.04 | |
| Regorafenib | Solvent control | 0.92±0.48 | 1.22±0.72 |
| Compound 4 | 0.43±0.10 | 0.55±0.10 | |
| Lenvatinib | Solvent control | 0.70±0.25 | 0.78±0.58 |
| Compound 4 | 0.10±0.05 | 0.10±0.01 | |
| Apatinib | Solvent control | 1.95±0.55 | 1.65±0.09 |
| Compound 4 | 0.53±0.20 | 0.59±0.07 | |
| Anlotinib | Solvent control | 1.70±0.54 | 1.60±0.71 |
| Compound 4 | 0.44±0.23 | 0.42±0.07 | |