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. 2020 Jul 27;13:7243–7255. doi: 10.2147/OTT.S257794

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© 2020 Han et al.

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The epigenetic mechanism underlying aberrant expression of APOB in low-grade glioma (LGG) revealed by bioinformatic analysis. (A) Heatmap of the association between expression of APOB mRNA and the methylation of APOB DNA CpG sites. (B) A negative correlation is observed between APOB mRNA and its DNA methylation (r=−0.355). (C) The levels of APOB mRNA are significantly higher in patients primary LGG than those with recurrent LGG (P=0.0082).