Table 2.

Cox Regression Analyses of Potential Risk Factors for OS in Patients with LGG from TCGA Database

	Univariate Regression			Multivariate Regression
	P value	HR	95% CI	P value	HR	95% CI
Age (≤50 vs >50)	<0.001	3.535	2.471–5.057	0.423	2.553	0.257–25.343
Gender (Female vs Male)	0.495	1.126	0.801–1.582	–	–	–
Race White/American Black/Africa American Asian	0.605	–	–	–	–	–
	0.317	1.477	0.688–3.170	–	–	–
	0.961	0.003	0.001–606.14	–	–	–
Histological Astrocytoma	0.009	–	–	0.585
Type Oligodendroglioma	0.002	0.546	0.370–0.806	0.311	0.244	0.016–3.726
Mixed	0.137	0.716	0.461–1.112	0.841	0.831	0.139–4.977
Laterality Left	0.343	–	–	–	–	–
Midline	0.154	1.290	0.909–1.832	–	–	–
Right	0.644	1.321	0.405–4.307	–	–	–
IDH1 (wildtype vs mutant)	0.001	0.181	0.068–0.485	0.789	1.245	0.250–6.207
KPS (>80 vs ≤80)	0.369	0.741	0.386–1.425	–	–	–
Radiotherapy (Yes vs No)	0.001	0.440	0.276–0.701	0.400	0.380	0.040–3.620
Family history of cancer
(Yes vs No)	0.039	1.575	1.023–2.425	0.539	1.948	0.232–16.381
Grade (III vs II)	<0.001	3.217	2.221–4.659	0.008	9.876	3.154–22.758
Seizure history (Yes vs No)	0.508	0.888	0.624–1.263	–	–	–
Cancer status (With tumor vs without tumor)	<0.001	24.072	5.938–97.585	0.939	13.41	0.012–89.131
MTD (>2cm vs ≤2)	0.743	0.789	0.191–3.259	–	–	–
Sample type (pLGG vs rLGG)	0.706	1.104	0.592–2.058	–	–	–
APOB mRNA (High vs Low)	0.007	1.627	1.144–2.313	0.286	4.807	0.269–85.770
Methylation (High vs Low)	<0.001	0.402	0.281–0.577	0.013	0.05	0.004–0.332

Abbreviations: OS, overall survival; KPS, Kamofsky performance status; WHO, World health organization; MTD, maximum tumor diameter; pLGG, primary low-grade glioma; rLGG, recurrent low-grade glioma.