Table 2.
Association between baseline serum indoxyl sulfate levels and clinical parameters
| Univariate | Multivariable | |||
|---|---|---|---|---|
| B (95% CI) | P | B (95% CI) | P | |
| Age (per 1 year increase) | 0.003 (−0.004 to 0.01) | 0.36 | – | |
| BMI (per 1 kg/m2 increase) | − 0.014 (− 0.035 to 0.008) | 0.22 | – | |
| SBP (per 1 mmHg increase) | 0.004 (− 0.004 to 0.012) | 0.31 | – | |
| eGFR (per 1 mL/min/1.73m2 increase) | −0.015 (− 0.022 to − 0.008) | < 0.001 | −0.013 (− 0.018 to0.001) | 0.02 |
| Log-transformed UPCR (per 1 increase) | 0.028 (−0.050 to 0.107) | 0.46 | – | |
| Hemoglobin (per 1 mg/dL increase) | −0.074 (− 0.123 to − 0.031) | 0.001 | −0.012 (− 0.059 to 0.034) | 0.60 |
| Phosphorus (per 1 mg/dL increase) | 0.263 (0.130 to 0.391) | < 0.001 | 0.085 (−0.053 to 0.224) | 0.22 |
| Intact PTH (per 1 mg/dL increase) | 0.002 (0.001 to 0.003) | < 0.001 | 0.001 (0.000 to 0.002) | 0.05 |
| serum albumin (per 1 g/dL increase) | −0.024 (− 0.183 to 0.135) | 0.77 | – | |
Abbreviation: BMI body mass index, SBP systolic blood pressure, eGFR estimated glomerular filtration rate, UPCR urine protein to creatinine ratio, PTH parathyroid hormone