Table 3.
Effect of Candidate Genes, Environment, and Their Interaction on MDD.
| Dependent Variables | β | SE | z | p Value |
|---|---|---|---|---|
| FoxO1 | ||||
| rs17592371 | −0.051 | 0.079 | −0.651 | 0.515 |
| CAs | 0.521 | 0.235 | 2.215 | 0.026 |
| rs17592371×CAs | 0.589 | 0.250 | 2.352 | 0.018 |
| rs17592371 | −0.156 | 0.121 | −1.285 | 0.198 |
| SLEs | 1.686 | 0.170 | 9.905 | <0.001 |
| rs17592371×SLEs | 0.468 | 0.171 | 2.739 | 0.006 |
| rs28553411 | −1.210 | 0.148 | −8.136 | <0.001 |
| CAs | 1.622 | 0.223 | 7.247 | <0.001 |
| rs28553411×CAs | 0.616 | 0.202 | 3.047 | 0.002 |
| rs17592371 | 1.881 | 0.393 | 4.781 | <0.001 |
| rs28553411 | −1.746 | 0.421 | −4.141 | <0.001 |
| rs17592371×rs28553411 | 0.275 | 0.108 | 2.547 | 0.010 |
| rs17592371 | 1.133 | 0.679 | 1.668 | 0.095 |
| rs28553411 | −1.219 | 0.679 | −1.796 | 0.072 |
| CAs | −0.083 | 0.202 | −0.413 | 0.679 |
| rs17592371×rs28553411×CAs | 0.321 | 0.109 | 2.922 | 0.003 |
| rs17592371 | 1.104 | 0.721 | 1.531 | 0.125 |
| rs28553411 | −1.226 | 0.721 | −1.700 | 0.089 |
| SLEs | 1.704 | 0.143 | 11.842 | <0.001 |
| rs17592371×rs28553411×SLEs | 0.211 | 0.087 | 2.409 | 0.016 |
| A2M | ||||
| rs10842847 | −0.142 | 0.120 | −1.181 | 0.238 |
| CAs | −0.133 | 0.183 | −0.725 | 0.468 |
| rs10842847×CAs | 0.894 | 0.371 | 2.409 | 0.016 |
| rs10842847 | −0.206 | 0.176 | −1.169 | 0.242 |
| SLEs | 1.152 | 0.124 | 9.273 | <0.001 |
| rs10842847×SLEs | 0.711 | 0.253 | 2.811 | 0.004 |
| rs10842849 | −0.166 | 0.121 | −1.372 | 0.170 |
| CAs | −0.129 | 0.184 | −0.704 | 0.481 |
| rs10842849×CAs | 0.988 | 0.374 | 2.639 | 0.008 |
| rs10842849 | −0.172 | 0.176 | −0.978 | 0.327 |
| SLEs | 1.283 | 0.124 | 10.309 | <0.001 |
| rs10842849×SLEs | 0.608 | 0.254 | 2.397 | 0.016 |
| rs226415 | 2.310 | 0.194 | 1.201 | 0.023 |
| SLEs | 2.310 | 0.134 | 17.136 | <0.001 |
| rs226415×SLEs | −0.697 | 0.251 | −2.775 | 0.005 |
| rs10842849 | 0.052 | 0.615 | 0.085 | 0.932 |
| rs226415 | 0.700 | 0.673 | 1.039 | 0.298 |
| rs10842849×rs226415 | −0.676 | 0.289 | −2.341 | 0.019 |
| rs10842849 | −0.123 | 0.625 | −0.197 | 0.843 |
| rs226415 | −0.060 | 0.631 | −0.095 | 0.924 |
| CAs | −0.141 | 0.183 | −0.768 | 0.442 |
| rs10842849×rs226415×CAs | 1.132 | 0.378 | 2.989 | 0.002 |
| TGF-β1 | ||||
| rs12461266 | −0.206 | 0.082 | −2.493 | 0.012 |
| CAs | −0.159 | 0.277 | −0.574 | 0.565 |
| rs12461266×CAs | 0.629 | 0.202 | 3.106 | 0.001 |
| rs12461266 | −0.276 | 0.124 | −2.218 | 0.026 |
| SLEs | 1.488 | 0.193 | 7.667 | <0.001 |
| rs12461266×SLEs | 0.527 | 0.167 | 3.146 | 0.001 |
| rs12983775 | 0.066 | 0.126 | 0.520 | 0.603 |
| SLEs | 2.363 | 0.204 | 11.563 | <0.001 |
| rs12983775×SLEs | −0.479 | 0.167 | −2.857 | 0.004 |
CAs, childhood adversities; SLEs, stressful life events.